Noduläres Paragranulom und Epstein-Barr-Virus: Häufigkeit von EBV-DNA und klinische Relevanz.

D. Rohde; H. Niedermeyer; C. Fellbaum; M. L. Hansmann; R. Busch; I. Lauder; H. Höfler; R. Fischer

Noduläres Paragranulom und Epstein-Barr-Virus: Häufigkeit von EBV-DNA und klinische Relevanz.

Translated title of the contribution: Nodular paragranuloma and Epstein-Barr virus: frequency of EBV DNA and clinical relevance

D. Rohde, H. Niedermeyer, C. Fellbaum, M. L. Hansmann, R. Busch, I. Lauder, H. Höfler, R. Fischer

University of Cologne

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Studies demonstrating Epstein-Barr virus (EBV) DNA in Hodgkin's disease (HD) provide little information about the EBV-status in the lymphocyte predominant subtype (nodular paragranuloma) which is due to the small number of cases investigated. Therefore we studied 99 typical cases of nodular paragranuloma for the presence of EBV-DNA using the polymerase chain reaction (PCR) technique. Genomic DNA was amplifiable in 71 cases; 29 cases (= 40%) were positive for EBV-DNA (EBNA-1). In situ hybridization revealed EBV-RNA (EBER-1) in L&H cells and in a few lymphocytes. PCR results were correlated to clinical follow-up data and did not show any statistically significant relationship between EBV positivity and survival of the patients.

Translated title of the contribution	Nodular paragranuloma and Epstein-Barr virus: frequency of EBV DNA and clinical relevance
Original language	German
Pages (from-to)	177-180
Number of pages	4
Journal	Verhandlungen der Deutschen Gesellschaft für Pathologie
Volume	76
State	Published - 1992
Externally published	Yes

Cite this

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title = "Nodul{\"a}res Paragranulom und Epstein-Barr-Virus: H{\"a}ufigkeit von EBV-DNA und klinische Relevanz.",

abstract = "Studies demonstrating Epstein-Barr virus (EBV) DNA in Hodgkin's disease (HD) provide little information about the EBV-status in the lymphocyte predominant subtype (nodular paragranuloma) which is due to the small number of cases investigated. Therefore we studied 99 typical cases of nodular paragranuloma for the presence of EBV-DNA using the polymerase chain reaction (PCR) technique. Genomic DNA was amplifiable in 71 cases; 29 cases (= 40%) were positive for EBV-DNA (EBNA-1). In situ hybridization revealed EBV-RNA (EBER-1) in L&H cells and in a few lymphocytes. PCR results were correlated to clinical follow-up data and did not show any statistically significant relationship between EBV positivity and survival of the patients.",

author = "D. Rohde and H. Niedermeyer and C. Fellbaum and Hansmann, {M. L.} and R. Busch and I. Lauder and H. H{\"o}fler and R. Fischer",

year = "1992",

language = "Deutsch",

volume = "76",

pages = "177--180",

journal = "Verhandlungen der Deutschen Gesellschaft f{\"u}r Pathologie",

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TY - JOUR

T1 - Noduläres Paragranulom und Epstein-Barr-Virus

T2 - Häufigkeit von EBV-DNA und klinische Relevanz.

AU - Rohde, D.

AU - Niedermeyer, H.

AU - Fellbaum, C.

AU - Hansmann, M. L.

AU - Busch, R.

AU - Lauder, I.

AU - Höfler, H.

AU - Fischer, R.

PY - 1992

Y1 - 1992

N2 - Studies demonstrating Epstein-Barr virus (EBV) DNA in Hodgkin's disease (HD) provide little information about the EBV-status in the lymphocyte predominant subtype (nodular paragranuloma) which is due to the small number of cases investigated. Therefore we studied 99 typical cases of nodular paragranuloma for the presence of EBV-DNA using the polymerase chain reaction (PCR) technique. Genomic DNA was amplifiable in 71 cases; 29 cases (= 40%) were positive for EBV-DNA (EBNA-1). In situ hybridization revealed EBV-RNA (EBER-1) in L&H cells and in a few lymphocytes. PCR results were correlated to clinical follow-up data and did not show any statistically significant relationship between EBV positivity and survival of the patients.

AB - Studies demonstrating Epstein-Barr virus (EBV) DNA in Hodgkin's disease (HD) provide little information about the EBV-status in the lymphocyte predominant subtype (nodular paragranuloma) which is due to the small number of cases investigated. Therefore we studied 99 typical cases of nodular paragranuloma for the presence of EBV-DNA using the polymerase chain reaction (PCR) technique. Genomic DNA was amplifiable in 71 cases; 29 cases (= 40%) were positive for EBV-DNA (EBNA-1). In situ hybridization revealed EBV-RNA (EBER-1) in L&H cells and in a few lymphocytes. PCR results were correlated to clinical follow-up data and did not show any statistically significant relationship between EBV positivity and survival of the patients.

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M3 - Artikel

C2 - 1283254

AN - SCOPUS:0027032869

SN - 0070-4113

VL - 76

SP - 177

EP - 180

JO - Verhandlungen der Deutschen Gesellschaft für Pathologie

JF - Verhandlungen der Deutschen Gesellschaft für Pathologie

ER -

Noduläres Paragranulom und Epstein-Barr-Virus: Häufigkeit von EBV-DNA und klinische Relevanz.

Abstract

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