@article{2a097e8be2ba4801a71ad23775c287b3,
title = "No cross-sectional and longitudinal association of ferritin and symptoms of attention-deficit-/hyperactivity disorder in a large population-based sample of children: Results from the GINIplus and LISAplus studies",
abstract = "Attention-deficit/hyperactivity disorder (ADHD) has been associated with alterations in iron metabolism, and low ferritin concentrations in peripheral blood have inconsistently been reported in clinically referred samples of children with ADHD. This study examined whether higher peripheral concentrations of ferritin, the major iron storage protein, are associated with decreased symptoms of ADHD in 2,805 children aged 10 years participating in two large population-based birth cohorts (GINIplus and LISAplus). Whether high ferritin concentrations at age 4 months predict lower ADHD symptoms at age 10 years was also investigated using a longitudinal approach in a subsample of 193 children. No indications for an association between peripheral ferritin concentrations and ADHD symptoms were found in this large population-based study. Re-evaluating iron substitution as a therapeutic measure for ADHD may be warranted.",
keywords = "ADHD, Attention-deficit/hyperactivity disorder, Children, Ferritin, Iron",
author = "Marcel Romanos and Tiesler, {Carla M.T.} and Sibylle Koletzko and Dietrich Berdel and {von Berg}, Andrea and Barbara Hoffmann and Beate Schaaf and Olf Herbarth and Irina Lehmann and Bauer, {Carl Peter} and Barbara Stach and Manfred Gerlach and Gerd Schulte-K{\"o}rne and Joachim Heinrich",
note = "Funding Information: Acknowledgments We thank the families for participation in the studies; the obstetric units for allowing recruitment, the GINI and LISA study teams for excellent work and several funding agencies listed below, and Elaine Fuertes for editorial assistance. The GINI intervention study was funded for 3 years by grants of the Federal Ministry for Education, Science, Research, and Technology (Grant No. 01 EE 9401-4), and Helmholtz Zentrum M{\"u}nchen, and the 6 and 10 years follow-up of the GINIplus study was funded by Helmholtz Zentrum M{\"u}nchen and in addition partly by the Federal Ministry of Environment (IUF, FKZ 20462296). The LISAplus study was funded by Helmholtz Zentrum M{\"u}nchen, by grants of the Federal Ministry of Environment, (BMU) (for IUF, FKZ 20462296), and Federal Ministry for Education, Science, Research, and Technology (No. 01 EG 9705/2 and 01EG9732). The study was further supported by a grant of the Friedrich Baur Foundation.",
year = "2013",
month = sep,
doi = "10.1007/s12402-013-0108-8",
language = "English",
volume = "5",
pages = "313--320",
journal = "ADHD Attention Deficit and Hyperactivity Disorders",
issn = "1866-6116",
publisher = "Springer-Verlag Wien",
number = "3",
}
