No background concentrations of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in blood of rats

Winfried Kessler, Wanwiwa Phokha, György A. Csanády, Johannes G. Filser

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We measured the background levels of di(2-ethylhexyl) phthalate (DEHP) and its hydrolytic metabolite mono(2-ethylhexyl) phthalate (MEHP) in blood from naive female Sprague-Dawley rats and in de-ionized charcoal-purified water using an analytical procedure that is based on sample treatment with acetonitrile, n-hexane extraction and analysis by gas chromatography. In blood, blank values of 91.3±34.7 μg DEHP/1 (n=31) and 30.1±13.1 μg MEHP/1 (n=20) were obtained, and in water, values of 91.6±44.2 μg DEHP/1 (n=26) and 26.7±10.4 μg MEHP/1 (n=15) were found. Since there is no difference between the background valves obtained from blood of naive rats and water, we conclude that DEHP and MEHP result from contamination during the analytical procedure.

Original languageEnglish
Pages (from-to)62-64
Number of pages3
JournalArchives of Toxicology
Volume75
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Blood
  • Di(2-ethylhexyl) phthalate
  • Mono(2-ethylhexyl) phthalate
  • Rat

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