No association of Vacuolar protein sorting 26 polymorphisms with Alzheimer's disease

M. Riemenschneider, A. Schoepfer-Wendels, P. Friedrich, L. Konta, S. M. Laws, J. C. Mueller, A. Kurz, H. Förstl

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.

Original languageEnglish
Pages (from-to)883-884
Number of pages2
JournalNeurobiology of Aging
Volume28
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Association study
  • Genetic analysis
  • VPS26

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