No association of lipase C polymorphisms with Alzheimer's disease

S. M. Laws, K. Eckart, P. Friedrich, T. Eisele, A. Kurz, H. Förstl, M. Riemenschneider

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism. As such this link makes LIPC a potential functional candidate for AD risk. Previously, three single nucleotide polymorphisms (SNPs) have been investigated in AD with a lack of association reported. To rule out a possible contribution of other variants in LIPC, located at 15q21-q23, we used a detailed fine mapping approach in a German case-control sample. Genotyping of 25 single nucleotide polymorphisms covering the complete LIPC gene and haplotypic analysis revealed no association with AD. Thus, we conclude that LIPC can be excluded as a major functional candidate gene conferring risk to AD.

Original languageEnglish
Pages (from-to)2192-2193
Number of pages2
JournalNeurobiology of Aging
Volume31
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Genetics
  • Hepatic lipase
  • LIPC

Fingerprint

Dive into the research topics of 'No association of lipase C polymorphisms with Alzheimer's disease'. Together they form a unique fingerprint.

Cite this