TY - JOUR
T1 - No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia
AU - Schumacher, Axel
AU - Friedrich, Patricia
AU - Diehl-Schmid, Janine
AU - Ibach, Bernd
AU - Eisele, Tamara
AU - Laws, Simon M.
AU - Förstl, Hans
AU - Kurz, Alexander
AU - Riemenschneider, Matthias
PY - 2007/11
Y1 - 2007/11
N2 - Mutations of the chromatin modifying protein 2B gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD). To explore the possible genetic contribution of common CHMP2B variants in sporadic FTD, we analyzed 14 single nucleotide polymorphisms covering the entire genomic region of CHMP2B. After adjustment for multiple testing single marker and haplotype analysis revealed no significant association with sporadic FTD. Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD.
AB - Mutations of the chromatin modifying protein 2B gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD). To explore the possible genetic contribution of common CHMP2B variants in sporadic FTD, we analyzed 14 single nucleotide polymorphisms covering the entire genomic region of CHMP2B. After adjustment for multiple testing single marker and haplotype analysis revealed no significant association with sporadic FTD. Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD.
KW - Association study
KW - CHMP2B
KW - Frontotemporal dementia
KW - Genetic analysis
KW - POU1F1
UR - http://www.scopus.com/inward/record.url?scp=34548544455&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2006.07.016
DO - 10.1016/j.neurobiolaging.2006.07.016
M3 - Article
C2 - 16979267
AN - SCOPUS:34548544455
SN - 0197-4580
VL - 28
SP - 1789
EP - 1790
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 11
ER -