NMR sample optimization and backbone assignment of a stabilized neurotensin receptor

Keyphrases

• G Protein-coupled Receptor 100%
• Backbone Assignment 100%
• Sampling Optimization 100%
• Neurotensin Receptor 100%
• Receptor Subtypes 66%
• Short Chain 33%
• NMR Spectroscopy 33%
• NMR Spectra 33%
• NMR Signal 33%
• Structural Features 33%
• Structural Change 33%
• NMR Experiments 33%
• Pharmaceutical Drugs 33%
• Phosphatidylcholine 33%
• Size Exclusion Chromatography 33%
• 2D NMR Experiments 33%
• Lipids 33%
• Signaling Cascades 33%
• Mode of Action 33%
• Cellular Signaling 33%
• Bound States 33%
• Functional State 33%
• Ligand Binding Site 33%
• Neurotensin 33%
• High-resolution Structures 33%
• High-resolution NMR 33%
• Functional Understanding 33%
• Membrane Mimetics 33%
• Amide Proton 33%
• Hydrogen-deuterium Exchange Mass Spectrometry 33%
• Back-exchange 33%
• Resonance Assignment 33%
• Transmembrane Region 33%
• NMR Characterization 33%
• Sample Heterogeneity 33%
• Amide Proton Exchange 33%
• Allosteric Ligands 33%
• Dynamical Features 33%
• Thermal Stability Test 33%

Biochemistry, Genetics and Molecular Biology

• G Protein Coupled Receptor 100%
• Neurotensin Receptor 100%
• Resonance Assignment 66%
• Agonist 66%
• Nuclear Magnetic Resonance Spectroscopy 33%
• Lipid 33%
• Two-Dimensional Nuclear Magnetic Resonance Spectroscopy 33%
• Ligand Binding 33%
• Thermostability 33%
• Size-Exclusion Chromatography 33%
• Hydrogen/Deuterium Exchange Mass Spectrometry 33%
• Binding Site 33%
• Phosphorylcholine 33%
• Neurotensin 33%

Immunology and Microbiology

• Vertebral Column 100%
• Neurotensin 100%
• Agonist 50%
• Resonance Assignment 50%
• Size Exclusion Chromatography 25%
• Nuclear Magnetic Resonance Spectroscopy 25%
• Two-Dimensional Nuclear Magnetic Resonance Spectroscopy 25%
• Thermostability 25%
• Hydrogen/Deuterium Exchange Mass Spectrometry 25%
• Binding Site 25%
• Ligand Binding 25%