TY - JOUR
T1 - Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression
AU - Ageeva-Kieferle, Alexandra
AU - Georgii, Elisabeth
AU - Winkler, Barbro
AU - Ghirardo, Andrea
AU - Albert, Andreas
AU - Hüther, Patrick
AU - Mengel, Alexander
AU - Becker, Claude
AU - Schnitzler, Jörg Peter
AU - Durner, Jörg
AU - Lindermayr, Christian
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/9
Y1 - 2021/9
N2 - Nitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. In addition to direct effects on transcriptional machinery, NO executes its signaling function via epigenetic mechanisms. We report that light intensity-dependent changes in NO correspond to changes in global histone acetylation (H3, H3K9, and H3K9/K14) in Arabidopsis (Arabidopsis thaliana) wild-type leaves, and that this relationship depends on S-nitrosoglutathione reductase and histone deacetylase 6 (HDA6). The activity of HDA6 was sensitive to NO, demonstrating that NO participates in regulation of histone acetylation. Chromatin immunoprecipitation sequencing and RNA-seq analyses revealed that NO participates in the metabolic switch from growth and development to stress response. This coordinating function of NO might be particularly important in plant ability to adapt to a changing environment, and is therefore a promising foundation for mitigating the negative effects of climate change on plant productivity.
AB - Nitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. In addition to direct effects on transcriptional machinery, NO executes its signaling function via epigenetic mechanisms. We report that light intensity-dependent changes in NO correspond to changes in global histone acetylation (H3, H3K9, and H3K9/K14) in Arabidopsis (Arabidopsis thaliana) wild-type leaves, and that this relationship depends on S-nitrosoglutathione reductase and histone deacetylase 6 (HDA6). The activity of HDA6 was sensitive to NO, demonstrating that NO participates in regulation of histone acetylation. Chromatin immunoprecipitation sequencing and RNA-seq analyses revealed that NO participates in the metabolic switch from growth and development to stress response. This coordinating function of NO might be particularly important in plant ability to adapt to a changing environment, and is therefore a promising foundation for mitigating the negative effects of climate change on plant productivity.
UR - http://www.scopus.com/inward/record.url?scp=85114433978&partnerID=8YFLogxK
U2 - 10.1093/plphys/kiab222
DO - 10.1093/plphys/kiab222
M3 - Article
C2 - 34003928
AN - SCOPUS:85114433978
SN - 0032-0889
VL - 187
SP - 336
EP - 360
JO - Plant Physiology
JF - Plant Physiology
IS - 1
ER -
