TY - JOUR
T1 - New Way to “SCORE” Risk
T2 - Updates on the ESC Scoring System and Incorporation into ESC Cardiovascular Prevention Guidelines
AU - on behalf of the European Society of Cardiology’s Cardiovascular Risk Collaboration (CRC)
AU - Graham, Ian M.
AU - Di Angelantonio, Emanuele
AU - Huculeci, Radu
AU - Graham, Ian M.
AU - Di Angelantonio, Emanuele
AU - De Bacquer, Dirk
AU - Ference, Brian
AU - Halle, Martin
AU - Huculeci, Radu
AU - McEvoy, John
AU - Timmis, Adam
AU - Vardas, Panos
AU - Visseren, Frank
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/11
Y1 - 2022/11
N2 - Purpose of Review: Prior European Society of Cardiology (ESC) guidelines endorsed the SCORE 10-year cardiovascular disease (CVD) risk calculator to inform the total risk approach to CVD prevention, including the use of preventive interventions like lipid lowering therapies. However, SCORE was released in 2003, did not allow for estimation of fatal and non-fatal CVD events, and was limited to adults aged 40 to 70 years. The ESC’s Cardiovascular Risk Collaboration (CRC) was tasked with updating SCORE (SCORE2) and with extending the upper age range of adults eligible for risk estimation (SCORE2-OP). This review summarises these two deliverables. Recent Findings: Published in 2021, these updated risk scores allow for estimation of 10 year total (fatal + non-fatal) risks of a first atherosclerotic cardiovascular event in adults (SCORE2) and older persons (SCORE2-OP), calibrated for use in four European risk regions. The models account for competing risk of non-CVD death. These were extensively validated with excellent calibration and C-statistics ranging from 0.67 to 0.81. Summary: SCORE2 and SCORE2-OP have informed the 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. In addition to endorsing these two updated risk calculators, these guidelines have, for the first time, recommended the use of age-related risk categories. This change was motivated to prevent overreliance on age when making CVD prevention decisions.
AB - Purpose of Review: Prior European Society of Cardiology (ESC) guidelines endorsed the SCORE 10-year cardiovascular disease (CVD) risk calculator to inform the total risk approach to CVD prevention, including the use of preventive interventions like lipid lowering therapies. However, SCORE was released in 2003, did not allow for estimation of fatal and non-fatal CVD events, and was limited to adults aged 40 to 70 years. The ESC’s Cardiovascular Risk Collaboration (CRC) was tasked with updating SCORE (SCORE2) and with extending the upper age range of adults eligible for risk estimation (SCORE2-OP). This review summarises these two deliverables. Recent Findings: Published in 2021, these updated risk scores allow for estimation of 10 year total (fatal + non-fatal) risks of a first atherosclerotic cardiovascular event in adults (SCORE2) and older persons (SCORE2-OP), calibrated for use in four European risk regions. The models account for competing risk of non-CVD death. These were extensively validated with excellent calibration and C-statistics ranging from 0.67 to 0.81. Summary: SCORE2 and SCORE2-OP have informed the 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. In addition to endorsing these two updated risk calculators, these guidelines have, for the first time, recommended the use of age-related risk categories. This change was motivated to prevent overreliance on age when making CVD prevention decisions.
KW - Atherosclerotic cardiovascular disease (CVD) risk factors
KW - Cardiovascular risk estimation
UR - http://www.scopus.com/inward/record.url?scp=85142934603&partnerID=8YFLogxK
U2 - 10.1007/s11886-022-01790-6
DO - 10.1007/s11886-022-01790-6
M3 - Review article
C2 - 36441402
AN - SCOPUS:85142934603
SN - 1523-3782
VL - 24
SP - 1679
EP - 1684
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 11
ER -
