New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann; Anika Großhennig; Peter S. Braund; Inke R. König; Christian Hengstenberg; Alistair S. Hall; Patrick Linsel-Nitschke; Sekar Kathiresan; Ben Wright; David Alexandre Trégouët; Francois Cambien; Petra Bruse; Zouhair Aherrahrou; Arnika K. Wagner; Klaus Stark; Stephen M. Schwartz; Veikko Salomaa; Roberto Elosua; Olle Melander; Benjamin F. Voight; Christopher J. O'Donnell; Leena Peltonen; David S. Siscovick; David Altshuler; Piera Angelica Merlini; Flora Peyvandi; Luisa Bernardinelli; Diego Ardissino; Arne Schillert; Stefan Blankenberg; Tanja Zeller; Philipp Wild; Daniel F. Schwarz; Laurence Tiret; Claire Perret; Stefan Schreiber; Nour Eddine El Mokhtari; Arne Schäfer; Winfried März; Wilfried Renner; Peter Bugert; Harald Klüter; Jürgen Schrezenmeir; Diana Rubin; Stephen G. Ball; Anthony J. Balmforth; H. Erich Wichmann; Thomas Meitinger; Marcus Fischer; Christa Meisinger; Jens Baumert; Annette Peters; Willem H. Ouwehand; Panos Deloukas; John R. Thompson; Andreas Ziegler; Nilesh J. Samani; Heribert Schunkert

doi:10.1038/ng.307

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann, Anika Großhennig, Peter S. Braund, Inke R. König, Christian Hengstenberg, Alistair S. Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K. Wagner, Klaus Stark, Stephen M. Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F. VoightChristopher J. O'Donnell, Leena Peltonen, David S. Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F. Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G. Ball, Anthony J. Balmforth, H. Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H. Ouwehand, Panos Deloukas, John R. Thompson, Andreas Ziegler, Nilesh J. Samani, Heribert Schunkert

Medicine and Health

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Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10^-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10^-7; OR = 1.08, 95% CI = 1.05-1.11).

Original language	English
Pages (from-to)	280-282
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	3
DOIs	https://doi.org/10.1038/ng.307
State	Published - Mar 2009

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Erdmann, J., Großhennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Trégouët, D. A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., ... Schunkert, H. (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nature Genetics, 41(3), 280-282. https://doi.org/10.1038/ng.307

@article{2db39413e99f4bb08158042f24913f90,

title = "New susceptibility locus for coronary artery disease on chromosome 3q22.3",

abstract = "We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10-7; OR = 1.08, 95% CI = 1.05-1.11).",

author = "Jeanette Erdmann and Anika Gro{\ss}hennig and Braund, {Peter S.} and K{\"o}nig, {Inke R.} and Christian Hengstenberg and Hall, {Alistair S.} and Patrick Linsel-Nitschke and Sekar Kathiresan and Ben Wright and Tr{\'e}gou{\"e}t, {David Alexandre} and Francois Cambien and Petra Bruse and Zouhair Aherrahrou and Wagner, {Arnika K.} and Klaus Stark and Schwartz, {Stephen M.} and Veikko Salomaa and Roberto Elosua and Olle Melander and Voight, {Benjamin F.} and O'Donnell, {Christopher J.} and Leena Peltonen and Siscovick, {David S.} and David Altshuler and Merlini, {Piera Angelica} and Flora Peyvandi and Luisa Bernardinelli and Diego Ardissino and Arne Schillert and Stefan Blankenberg and Tanja Zeller and Philipp Wild and Schwarz, {Daniel F.} and Laurence Tiret and Claire Perret and Stefan Schreiber and Mokhtari, {Nour Eddine El} and Arne Sch{\"a}fer and Winfried M{\"a}rz and Wilfried Renner and Peter Bugert and Harald Kl{\"u}ter and J{\"u}rgen Schrezenmeir and Diana Rubin and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Wichmann, {H. Erich} and Thomas Meitinger and Marcus Fischer and Christa Meisinger and Jens Baumert and Annette Peters and Ouwehand, {Willem H.} and Panos Deloukas and Thompson, {John R.} and Andreas Ziegler and Samani, {Nilesh J.} and Heribert Schunkert",

note = "Funding Information: Germany) for database management. The German Study was supported by the Deutsche Forschungsgemeinschaft and the German Federal Ministry of Education and Research (BMBF) in the context of the German National Genome Research Network (NGFN-2 and NGFN-plus). The WTCCC Study was funded by the Wellcome Trust. Recruitment of cases for the WTCCC Study was carried out by the British Heart Foundation (BHF) Family Heart Study Research Group and supported by the BHF and the UK Medical Research Council. We also acknowledge support of the Wellcome Trust Functional Genomics Initiative in Cardiovascular Genetics. The KORA research platform (KORA, Cooperative Research in the Region of Augsburg) was initiated and financed by the GSF-National Research Centre for Environment and Health, which is funded by the German Federal Ministry of Education and Research and of the State of Bavaria. N.J.S. and S.G.B. are supported by Chairs funded by the BHF. Recruitment for the Italian Atherosclerosis, Thrombosis and Vascular Biology Working Group was supported by the {\textquoteleft}{\textquoteleft}Associazione per lo Studio della Trombosi in Cardiologia.{\textquoteright}{\textquoteright} The MIGen/ IATVB genotyping was supported by a grant to D. Altshuler (R01HL087676) from the STAMPEED program of the National Heart, Lung, and Blood Institute, US National Institutes of Health. In addition, the MIGen study was supported by grants from the Fannie Rippel Foundation (to S.K.) and the Doris Duke Charitable Foundation (to S.K.). The Broad Institute Center for Genotyping and Analysis subsidized genotyping in the MIGen study with support from the National Center for Research Resources (U54RR020278). The main sponsor of the current analysis is the EU-funded integrated project Cardiogenics (LSHM-CT-2006-037593).",

year = "2009",

month = mar,

doi = "10.1038/ng.307",

language = "English",

volume = "41",

pages = "280--282",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "3",

}

Erdmann, J, Großhennig, A, Braund, PS, König, IR, Hengstenberg, C, Hall, AS, Linsel-Nitschke, P, Kathiresan, S, Wright, B, Trégouët, DA, Cambien, F, Bruse, P, Aherrahrou, Z, Wagner, AK, Stark, K, Schwartz, SM, Salomaa, V, Elosua, R, Melander, O, Voight, BF, O'Donnell, CJ, Peltonen, L, Siscovick, DS, Altshuler, D, Merlini, PA, Peyvandi, F, Bernardinelli, L, Ardissino, D, Schillert, A, Blankenberg, S, Zeller, T, Wild, P, Schwarz, DF, Tiret, L, Perret, C, Schreiber, S, Mokhtari, NEE, Schäfer, A, März, W, Renner, W, Bugert, P, Klüter, H, Schrezenmeir, J, Rubin, D, Ball, SG, Balmforth, AJ, Wichmann, HE, Meitinger, T, Fischer, M, Meisinger, C, Baumert, J, Peters, A, Ouwehand, WH, Deloukas, P, Thompson, JR, Ziegler, A, Samani, NJ & Schunkert, H 2009, 'New susceptibility locus for coronary artery disease on chromosome 3q22.3', Nature Genetics, vol. 41, no. 3, pp. 280-282. https://doi.org/10.1038/ng.307

TY - JOUR

T1 - New susceptibility locus for coronary artery disease on chromosome 3q22.3

AU - Erdmann, Jeanette

AU - Großhennig, Anika

AU - Braund, Peter S.

AU - König, Inke R.

AU - Hengstenberg, Christian

AU - Hall, Alistair S.

AU - Linsel-Nitschke, Patrick

AU - Kathiresan, Sekar

AU - Wright, Ben

AU - Trégouët, David Alexandre

AU - Cambien, Francois

AU - Bruse, Petra

AU - Aherrahrou, Zouhair

AU - Wagner, Arnika K.

AU - Stark, Klaus

AU - Schwartz, Stephen M.

AU - Salomaa, Veikko

AU - Elosua, Roberto

AU - Melander, Olle

AU - Voight, Benjamin F.

AU - O'Donnell, Christopher J.

AU - Peltonen, Leena

AU - Siscovick, David S.

AU - Altshuler, David

AU - Merlini, Piera Angelica

AU - Peyvandi, Flora

AU - Bernardinelli, Luisa

AU - Ardissino, Diego

AU - Schillert, Arne

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Wild, Philipp

AU - Schwarz, Daniel F.

AU - Tiret, Laurence

AU - Perret, Claire

AU - Schreiber, Stefan

AU - Mokhtari, Nour Eddine El

AU - Schäfer, Arne

AU - März, Winfried

AU - Renner, Wilfried

AU - Bugert, Peter

AU - Klüter, Harald

AU - Schrezenmeir, Jürgen

AU - Rubin, Diana

AU - Ball, Stephen G.

AU - Balmforth, Anthony J.

AU - Wichmann, H. Erich

AU - Meitinger, Thomas

AU - Fischer, Marcus

AU - Meisinger, Christa

AU - Baumert, Jens

AU - Peters, Annette

AU - Ouwehand, Willem H.

AU - Deloukas, Panos

AU - Thompson, John R.

AU - Ziegler, Andreas

AU - Samani, Nilesh J.

AU - Schunkert, Heribert

N1 - Funding Information: Germany) for database management. The German Study was supported by the Deutsche Forschungsgemeinschaft and the German Federal Ministry of Education and Research (BMBF) in the context of the German National Genome Research Network (NGFN-2 and NGFN-plus). The WTCCC Study was funded by the Wellcome Trust. Recruitment of cases for the WTCCC Study was carried out by the British Heart Foundation (BHF) Family Heart Study Research Group and supported by the BHF and the UK Medical Research Council. We also acknowledge support of the Wellcome Trust Functional Genomics Initiative in Cardiovascular Genetics. The KORA research platform (KORA, Cooperative Research in the Region of Augsburg) was initiated and financed by the GSF-National Research Centre for Environment and Health, which is funded by the German Federal Ministry of Education and Research and of the State of Bavaria. N.J.S. and S.G.B. are supported by Chairs funded by the BHF. Recruitment for the Italian Atherosclerosis, Thrombosis and Vascular Biology Working Group was supported by the ‘‘Associazione per lo Studio della Trombosi in Cardiologia.’’ The MIGen/ IATVB genotyping was supported by a grant to D. Altshuler (R01HL087676) from the STAMPEED program of the National Heart, Lung, and Blood Institute, US National Institutes of Health. In addition, the MIGen study was supported by grants from the Fannie Rippel Foundation (to S.K.) and the Doris Duke Charitable Foundation (to S.K.). The Broad Institute Center for Genotyping and Analysis subsidized genotyping in the MIGen study with support from the National Center for Research Resources (U54RR020278). The main sponsor of the current analysis is the EU-funded integrated project Cardiogenics (LSHM-CT-2006-037593).

PY - 2009/3

Y1 - 2009/3

N2 - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10-7; OR = 1.08, 95% CI = 1.05-1.11).

AB - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10-7; OR = 1.08, 95% CI = 1.05-1.11).

UR - http://www.scopus.com/inward/record.url?scp=61349177857&partnerID=8YFLogxK

U2 - 10.1038/ng.307

DO - 10.1038/ng.307

M3 - Article

C2 - 19198612

AN - SCOPUS:61349177857

SN - 1061-4036

VL - 41

SP - 280

EP - 282

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

New susceptibility locus for coronary artery disease on chromosome 3q22.3

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