New ruthenium catalysts for asymmetric transfer hydrogenation of prochiral ketones

Stephan Enthaler, Bernhard Hagemann, Santosh Bhor, Gopinathan Anilkumar, Man Kin Tse, Bianca Bitterlich, Kathrin Junge, Giulia Erre, Matthias Beller

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Tridentate N,N,N-pyridinebisimidazolines have been studied as new ligands for the enantioselective transfer hydrogenation of prochiral ketones. High yields and excellent enantioselectivity up to >99 % ee have been achieved with an in situ generated catalytic system containing dichlorotris(triphenylphosphine)ruthenium and 2,6-bis-([4R,5R]-4,5-diphenyl-4,5- dihydro-1H-imidazol-2-yl)-pyridine (3a) in the presence of sodium isopropoxide.

Original languageEnglish
Pages (from-to)853-860
Number of pages8
JournalAdvanced Synthesis and Catalysis
Volume349
Issue number6
DOIs
StatePublished - Apr 2007
Externally publishedYes

Keywords

  • Asymmetric transfer hydrogenation
  • Ketones
  • Phosphines
  • Ruthenium
  • Tridentate nitrogen ligands

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