New immunopathologic insights into multiple sclerosis

Bernhard Hemmer, Bernd Kieseier, Sabine Cepok, Hans Peter Hartung

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Athough the immune system seems to play an important role in the pathogenesis of disease, target antigens are still uncertain and pathways leading to tissue destruction have not been fully elucidated. Recent studies have significantly contributed to a better understanding of the disease process and broadened our view on possible scenarios of disease initiation and progression. We review the role of the immune system for the manifestation and evolution of MS and discuss different pathogenetic concepts. We conclude with an outlook on future strategies to identify the cause of MS.

Original languageEnglish
Pages (from-to)246-255
Number of pages10
JournalCurrent Neurology and Neuroscience Reports
Volume3
Issue number3
DOIs
StatePublished - May 2003
Externally publishedYes

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