New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Margot Wenzel; Emilia Bigaeva; Philippe Richard; Pierre Le Gendre; Michel Picquet; Angela Casini; Ewen Bodio

doi:10.1016/j.jinorgbio.2014.07.011

New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Margot Wenzel, Emilia Bigaeva, Philippe Richard, Pierre Le Gendre, Michel Picquet, Angela Casini, Ewen Bodio

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

Original language	English
Pages (from-to)	10-16
Number of pages	7
Journal	Journal of Inorganic Biochemistry
Volume	141
DOIs	https://doi.org/10.1016/j.jinorgbio.2014.07.011
State	Published - Dec 2014
Externally published	Yes

Keywords

Anticancer agent
Gold complex
Heteronuclear complex
Platinum complex
Thioglucose

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jinorgbio.2014.07.011

Cite this

@article{dae34c6ae1d141368a527056c304c6be,

title = "New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?",

abstract = "A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.",

keywords = "Anticancer agent, Gold complex, Heteronuclear complex, Platinum complex, Thioglucose",

author = "Margot Wenzel and Emilia Bigaeva and Philippe Richard and {Le Gendre}, Pierre and Michel Picquet and Angela Casini and Ewen Bodio",

note = "Funding Information: A.C. thanks the University of Groningen (Rosalind Franklin Fellowship) for funding. COST Action CM1105 is acknowledged for providing opportunities of discussion. E.B. thanks the Conseil R{\'e}gional de Bourgogne (PARI and 3MIM programs) and the Centre National de la Recherche Scientifique ( CNRS ) for financial support. The Minist{\`e}re de l'Enseignement Sup{\'e}rieur et de la Recherche is acknowledged for a Ph. D. grant to M.W. Dr F. Picquet and Ms M.-J. Penouilh are gratefully acknowledged for HR-MS analyses. Prof. A. Quiroga and Dr. M.S. Meier are kindly acknowledged for providing an amount of 9-EtG. ",

year = "2014",

month = dec,

doi = "10.1016/j.jinorgbio.2014.07.011",

language = "English",

volume = "141",

pages = "10--16",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties

T2 - Are two metals better than one?

AU - Wenzel, Margot

AU - Bigaeva, Emilia

AU - Richard, Philippe

AU - Le Gendre, Pierre

AU - Picquet, Michel

AU - Casini, Angela

AU - Bodio, Ewen

N1 - Funding Information: A.C. thanks the University of Groningen (Rosalind Franklin Fellowship) for funding. COST Action CM1105 is acknowledged for providing opportunities of discussion. E.B. thanks the Conseil Régional de Bourgogne (PARI and 3MIM programs) and the Centre National de la Recherche Scientifique ( CNRS ) for financial support. The Ministère de l'Enseignement Supérieur et de la Recherche is acknowledged for a Ph. D. grant to M.W. Dr F. Picquet and Ms M.-J. Penouilh are gratefully acknowledged for HR-MS analyses. Prof. A. Quiroga and Dr. M.S. Meier are kindly acknowledged for providing an amount of 9-EtG.

PY - 2014/12

Y1 - 2014/12

N2 - A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

AB - A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

KW - Anticancer agent

KW - Gold complex

KW - Heteronuclear complex

KW - Platinum complex

KW - Thioglucose

UR - http://www.scopus.com/inward/record.url?scp=84906834058&partnerID=8YFLogxK

U2 - 10.1016/j.jinorgbio.2014.07.011

DO - 10.1016/j.jinorgbio.2014.07.011

M3 - Article

C2 - 25172993

AN - SCOPUS:84906834058

SN - 0162-0134

VL - 141

SP - 10

EP - 16

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this