New classification of tauopathies

G. U. Höglinger, G. Respondek, G. G. Kovacs

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.

Original languageEnglish
Pages (from-to)664-668
Number of pages5
JournalRevue Neurologique
Volume174
Issue number9
DOIs
StatePublished - Nov 2018
Externally publishedYes

Keywords

  • Corticobasal degeneration
  • Corticobasal syndrome
  • Progressive supranuclear palsy
  • Richardson's syndrome
  • Tauopathies

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