TY - JOUR
T1 - New aspects in the treatment of acute coronary syndromes without ST-elevation
T2 - ICTUS and ISAR-COOL in perspective
AU - Neumann, Franz Josef
AU - Kastrati, Adnan
AU - Schwarzer, Guido
PY - 2007/2
Y1 - 2007/2
N2 - For treatment of patients with high-risk acute coronary syndromes, current guidelines recommend early coronary angiography and coronary revascularization, when feasible, irrespective of the primary success of medical treatment. Moreover, the results of a randomized trial (ISAR-COOL) suggested performing revascularization as early as possible. The concept of systematic coronary angiography and revascularization in high-risk acute coronary syndromes has been challenged recently by another randomized study (ICTUS) demonstrating an excess of myocardial infarction during 1-year follow-up with a routine-invasive strategy when compared with a selectively invasive strategy. This review intends to put the new trial results in perspective with evidence from previous studies.
AB - For treatment of patients with high-risk acute coronary syndromes, current guidelines recommend early coronary angiography and coronary revascularization, when feasible, irrespective of the primary success of medical treatment. Moreover, the results of a randomized trial (ISAR-COOL) suggested performing revascularization as early as possible. The concept of systematic coronary angiography and revascularization in high-risk acute coronary syndromes has been challenged recently by another randomized study (ICTUS) demonstrating an excess of myocardial infarction during 1-year follow-up with a routine-invasive strategy when compared with a selectively invasive strategy. This review intends to put the new trial results in perspective with evidence from previous studies.
KW - Acute coronary syndromes
KW - Guidelines
KW - Meta-analysis
KW - Percutaneous catheter intervention
KW - Timing
KW - Treatment strategies
UR - http://www.scopus.com/inward/record.url?scp=33847152066&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/sul068
DO - 10.1093/eurheartj/sul068
M3 - Review article
AN - SCOPUS:33847152066
SN - 1520-765X
VL - 9
SP - A4-A10
JO - European Heart Journal, Supplement
JF - European Heart Journal, Supplement
IS - A
ER -