New aspects in the treatment of acute coronary syndromes without ST-elevation: ICTUS and ISAR-COOL in perspective

Franz Josef Neumann, Adnan Kastrati, Guido Schwarzer

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

For treatment of patients with high-risk acute coronary syndromes, current guidelines recommend early coronary angiography and coronary revascularization, when feasible, irrespective of the primary success of medical treatment. Moreover, the results of a randomized trial (ISAR-COOL) suggested performing revascularization as early as possible. The concept of systematic coronary angiography and revascularization in high-risk acute coronary syndromes has been challenged recently by another randomized study (ICTUS) demonstrating an excess of myocardial infarction during 1-year follow-up with a routine-invasive strategy when compared with a selectively invasive strategy. This review intends to put the new trial results in perspective with evidence from previous studies.

Original languageEnglish
Pages (from-to)A4-A10
JournalEuropean Heart Journal, Supplement
Volume9
Issue numberA
DOIs
StatePublished - Feb 2007

Keywords

  • Acute coronary syndromes
  • Guidelines
  • Meta-analysis
  • Percutaneous catheter intervention
  • Timing
  • Treatment strategies

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