Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Philipp Kruger; Mona Saffarzadeh; Alexander N.R. Weber; Nikolaus Rieber; Markus Radsak; Horst von Bernuth; Charaf Benarafa; Dirk Roos; Julia Skokowa; Dominik Hartl

doi:10.1371/journal.ppat.1004651

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Philipp Kruger, Mona Saffarzadeh, Alexander N.R. Weber, Nikolaus Rieber, Markus Radsak, Horst von Bernuth, Charaf Benarafa, Dirk Roos, Julia Skokowa, Dominik Hartl

Research output: Contribution to journal › Review article › peer-review

515 Scopus citations

Abstract

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

Original language	English
Article number	e1004651
Pages (from-to)	1-22
Number of pages	22
Journal	PLoS Pathogens
Volume	11
Issue number	3
DOIs	https://doi.org/10.1371/journal.ppat.1004651
State	Published - 1 Mar 2015
Externally published	Yes

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title = "Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury",

abstract = "Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.",

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AU - Kruger, Philipp

AU - Saffarzadeh, Mona

AU - Weber, Alexander N.R.

AU - Rieber, Nikolaus

AU - Radsak, Markus

AU - von Bernuth, Horst

AU - Benarafa, Charaf

AU - Roos, Dirk

AU - Skokowa, Julia

AU - Hartl, Dominik

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AB - Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

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Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Abstract

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