Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Philipp Kruger, Mona Saffarzadeh, Alexander N.R. Weber, Nikolaus Rieber, Markus Radsak, Horst von Bernuth, Charaf Benarafa, Dirk Roos, Julia Skokowa, Dominik Hartl

Research output: Contribution to journalReview articlepeer-review

484 Scopus citations

Abstract

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

Original languageEnglish
Article numbere1004651
Pages (from-to)1-22
Number of pages22
JournalPLoS Pathogens
Volume11
Issue number3
DOIs
StatePublished - 1 Mar 2015
Externally publishedYes

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