Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions

Robert Blum; Arthur Konnerth

doi:10.1152/physiol.00042.2004

Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions

Robert Blum
, Arthur Konnerth

Ludwig-Maximilians-Universität München

Research output: Contribution to journal › Review article › peer-review

209 Scopus citations

Abstract

Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.

Original language	English
Pages (from-to)	70-78
Number of pages	9
Journal	Physiology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00042.2004
State	Published - Feb 2005
Externally published	Yes

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10.1152/physiol.00042.2004

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AB - Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.

UR - https://www.scopus.com/pages/publications/14744272637

U2 - 10.1152/physiol.00042.2004

DO - 10.1152/physiol.00042.2004

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JO - Physiology

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Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions

Abstract

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