Neurotrophin-3 (NT-3) as a Potential Biomarker of the Peripheral Nervous System Damage Following Breast Cancer Treatment

Samvel Tonyan, Maria Pospelova, Varvara Krasnikova, Olga Fionik, Tatyana Alekseeva, Konstantin Samochernykh, Nataliya Ivanova, Tatyana Vavilova, Elena Vasilieva, Albina Makhanova, Aleksandra Nikolaeva, Tatyana Bukkieva, Stephanie Combs, Maxim Shevtsov

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Damage to the peripheral nervous system (PNS) is a common complication of breast cancer (BC) treatment, with 60 to 80% of breast cancer survivors experiencing symptoms of PNS damage. In the current study, the levels of brain-derived neurotrophic factor (BDNF), galectin-3 (Gal-3), and neurotrophin-3 (NT-3) were measured in the blood serum of BC patients by ELISA as potential biomarkers that might indicate the PNS damage. Sixty-seven patients were enrolled in this multi-center trial and compared to the aged-matched healthy female volunteers (control group) (n = 25). Intergroup comparison of biomarker levels (i.e., Gal-3 and BDNF) did not show significant differences in any of the studied subgroups. However, intriguingly, NT-3 levels were significantly higher in BC patients as compared to healthy volunteers, constituting 14.85 [10.3; 18.0] and 5.74 [4.56; 13.7] pg/mL, respectively (p < 0.001). In conclusion, NT-3 might be employed as a potential biomarker in BC patients with clinical manifestations of PNS damage. However, further studies to validate its correlation to the degree of peripheral nervous system lesions are of high value.

Original languageEnglish
Pages (from-to)110-122
Number of pages13
JournalPathophysiology
Volume30
Issue number2
DOIs
StatePublished - Jun 2023

Keywords

  • BDNF
  • brain-derived neurotrophic factor
  • breast cancer
  • chemotherapy-induced peripheral neuropathy
  • galectin-3
  • mastectomy
  • neuropathy
  • neurotrophin-3
  • peripheral nervous system
  • postmastectomy pain syndrome
  • radiation-induced peripheral neuropathy

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