Neue erkenntnisse zur pathogenese der acne inversa

Anisa Hana; Giovanni Frongia; Alexei Gratchev; Sergij Goerdt; Hjalmar Kurzen

Neue erkenntnisse zur pathogenese der acne inversa

Translated title of the contribution: New findings into the pathogensis acne inversa

Anisa Hana, Giovanni Frongia, Alexei Gratchev, Sergij Goerdt, Hjalmar Kurzen

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Acne inversa is triggered by tobacco-smoking. Nicotine acts as a specific ligand on nicotinic acetylcholine receptors (nAChR). In human skin, the highest density of AChR and the highest amount of ACh can be found periinfundibularly, especially in lesions of acne inversa. We were able to detect subtypes of nAChR on which nicotine acts as an agonist - and such on which it acts as an antagonist. We could demonstrate that nicotine influences basic pathomechanisms of acne inversa via AChR both in vitro and in vivo.

Translated title of the contribution	New findings into the pathogensis acne inversa
Original language	German
Pages (from-to)	158-160
Number of pages	3
Journal	Haut
Volume	18
Issue number	4
State	Published - Aug 2007
Externally published	Yes

Cite this

@article{d44e6e7f94ab498d91f332ac1ab5a0fb,

title = "Neue erkenntnisse zur pathogenese der acne inversa",

abstract = "Acne inversa is triggered by tobacco-smoking. Nicotine acts as a specific ligand on nicotinic acetylcholine receptors (nAChR). In human skin, the highest density of AChR and the highest amount of ACh can be found periinfundibularly, especially in lesions of acne inversa. We were able to detect subtypes of nAChR on which nicotine acts as an agonist - and such on which it acts as an antagonist. We could demonstrate that nicotine influences basic pathomechanisms of acne inversa via AChR both in vitro and in vivo.",

keywords = "Acetylcholine, Inflammation, Skin",

author = "Anisa Hana and Giovanni Frongia and Alexei Gratchev and Sergij Goerdt and Hjalmar Kurzen",

year = "2007",

month = aug,

language = "Deutsch",

volume = "18",

pages = "158--160",

journal = "Haut",

issn = "0938-2216",

publisher = "WPV Wirtschafts- und Praxisverlag GmbH",

number = "4",

}

TY - JOUR

T1 - Neue erkenntnisse zur pathogenese der acne inversa

AU - Hana, Anisa

AU - Frongia, Giovanni

AU - Gratchev, Alexei

AU - Goerdt, Sergij

AU - Kurzen, Hjalmar

PY - 2007/8

Y1 - 2007/8

N2 - Acne inversa is triggered by tobacco-smoking. Nicotine acts as a specific ligand on nicotinic acetylcholine receptors (nAChR). In human skin, the highest density of AChR and the highest amount of ACh can be found periinfundibularly, especially in lesions of acne inversa. We were able to detect subtypes of nAChR on which nicotine acts as an agonist - and such on which it acts as an antagonist. We could demonstrate that nicotine influences basic pathomechanisms of acne inversa via AChR both in vitro and in vivo.

AB - Acne inversa is triggered by tobacco-smoking. Nicotine acts as a specific ligand on nicotinic acetylcholine receptors (nAChR). In human skin, the highest density of AChR and the highest amount of ACh can be found periinfundibularly, especially in lesions of acne inversa. We were able to detect subtypes of nAChR on which nicotine acts as an agonist - and such on which it acts as an antagonist. We could demonstrate that nicotine influences basic pathomechanisms of acne inversa via AChR both in vitro and in vivo.

KW - Acetylcholine

KW - Inflammation

KW - Skin

UR - http://www.scopus.com/inward/record.url?scp=34848915089&partnerID=8YFLogxK

M3 - Kurzer Abriss

AN - SCOPUS:34848915089

SN - 0938-2216

VL - 18

SP - 158

EP - 160

JO - Haut

JF - Haut

IS - 4

ER -

Neue erkenntnisse zur pathogenese der acne inversa

Abstract

Other files and links

Fingerprint

Cite this