Abstract
The peripheral nervous system may influence immune responses through the release of neuropeptides such as CGRP. Tissue concentrations of CGRP rapidly increase in response to infection and inflammation. This review will focus on the regulatory effects of CGRP on innate and adaptive immune responses and the role of CGRP in inflammatory disorders. Current concepts for the molecular basis of these effects are discussed. It is proposed that CGRP mediates a potent peptidergic antiinflammatory pathway.
Original language | English |
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Title of host publication | Nerve-Driven Immunity |
Subtitle of host publication | Neurotransmitters and Neuropeptides in the Immune System |
Publisher | Springer-Verlag Wien |
Pages | 289-306 |
Number of pages | 18 |
ISBN (Electronic) | 9783709108888 |
ISBN (Print) | 9783709108871 |
DOIs | |
State | Published - 1 Jan 2012 |
Externally published | Yes |