TY - JOUR
T1 - Near-infrared photoacoustic imaging probe responsive to calcium
AU - Mishra, Anurag
AU - Jiang, Yuanyuan
AU - Roberts, Sheryl
AU - Ntziachristos, Vasilis
AU - Westmeyer, Gil G.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.
AB - Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.
UR - http://www.scopus.com/inward/record.url?scp=85045559415&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.6b03039
DO - 10.1021/acs.analchem.6b03039
M3 - Article
AN - SCOPUS:85045559415
SN - 0003-2700
VL - 88
SP - 10785
EP - 10789
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 22
ER -