Abstract
The directed application of force to different points on the surface of the green fluorescent protein (GFP) makes it possible to shift between two different pathways with distinct unfolding intermediates. One pathway resembles a "folding-like" pathway, whereas the other may play a role during processes such as import through a pore. The picture shows the energy landscape of GFP with intermediates and pathways. (Figure Presented)
Original language | English |
---|---|
Pages (from-to) | 8192-8195 |
Number of pages | 4 |
Journal | Angewandte Chemie International Edition in English |
Volume | 47 |
Issue number | 43 |
DOIs | |
State | Published - 13 Oct 2008 |
Keywords
- Protein engineering
- Protein folding
- Protein structures
- Scanning probe microscopy
- Single-molecule studies