TY - JOUR
T1 - Native fluorescence of platelets from patients with occlusive arterial disease
AU - Lohmann, Wolfgang
AU - Lohmann, Chris
N1 - Funding Information:
Deutsche Forschungsgemeinschaft, the Hoechst Co., and from the Fonds der Chemischen Industrie. We would like to thank Prof. G. M~ller-Berghaus for giving one of us (Ch.L.) the opportunity for preparing the platelets and Dr.S.K. Bowry for advice.
PY - 1988/5/16
Y1 - 1988/5/16
N2 - Healthy platelets exhibit a fluorescence band with a peak at 475 nm if excited at 360 nm. This peak increases first with the progression of occlusive arterial disease (OAD) followed by a decrease at an advanced stage. Concomitantly, a new fluorescence band at 445 nm will appear, which increases steadily with the progression of OAD. These findings can be explained by the oxidation of NADH (fluorescence at 475 nm) to NAD (445 nm) and support, thus, the assumption that oxidative processes are involved in the formation of OAD.
AB - Healthy platelets exhibit a fluorescence band with a peak at 475 nm if excited at 360 nm. This peak increases first with the progression of occlusive arterial disease (OAD) followed by a decrease at an advanced stage. Concomitantly, a new fluorescence band at 445 nm will appear, which increases steadily with the progression of OAD. These findings can be explained by the oxidation of NADH (fluorescence at 475 nm) to NAD (445 nm) and support, thus, the assumption that oxidative processes are involved in the formation of OAD.
UR - http://www.scopus.com/inward/record.url?scp=0023908626&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(88)80442-X
DO - 10.1016/S0006-291X(88)80442-X
M3 - Article
C2 - 3377778
AN - SCOPUS:0023908626
SN - 0006-291X
VL - 152
SP - 1410
EP - 1415
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -