TY - JOUR
T1 - Nanoparticle-based immunosensors and immunoassays for aflatoxins
AU - Wang, Xu
AU - Niessner, Reinhard
AU - Tang, Dianping
AU - Knopp, Dietmar
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/3/17
Y1 - 2016/3/17
N2 - Aflatoxins are naturally existing mycotoxins produced mainly by Aspergillus flavus and Aspergillus parasiticus, present in a wide range of food and feed products. Because of their extremely high toxicity and carcinogenicity, strict control of maximum residue levels of aflatoxins in foodstuff is set by many countries. In daily routine, different chromatographic methods are used almost exclusively. As supplement, in several companies enzyme immunoassay-based sample testing as primary screening is performed. Recently, nanomaterials such as noble metal nanoparticles, magnetic particles, carbon nanomaterials, quantum dots, and silica nanomaterials are increasingly utilized for aflatoxin determination to improve the sensitivity and simplify the detection. They are employed either as supports for the immobilization of biomolecules or as electroactive or optical labels for signal transduction and amplification. Several nanoparticle-based electrochemical, piezoelectric, optical, and immunodipstick assays for aflatoxins have been developed. In this review, we summarize these recent advances and illustrate novel concepts and promising applications in the field of food safety.
AB - Aflatoxins are naturally existing mycotoxins produced mainly by Aspergillus flavus and Aspergillus parasiticus, present in a wide range of food and feed products. Because of their extremely high toxicity and carcinogenicity, strict control of maximum residue levels of aflatoxins in foodstuff is set by many countries. In daily routine, different chromatographic methods are used almost exclusively. As supplement, in several companies enzyme immunoassay-based sample testing as primary screening is performed. Recently, nanomaterials such as noble metal nanoparticles, magnetic particles, carbon nanomaterials, quantum dots, and silica nanomaterials are increasingly utilized for aflatoxin determination to improve the sensitivity and simplify the detection. They are employed either as supports for the immobilization of biomolecules or as electroactive or optical labels for signal transduction and amplification. Several nanoparticle-based electrochemical, piezoelectric, optical, and immunodipstick assays for aflatoxins have been developed. In this review, we summarize these recent advances and illustrate novel concepts and promising applications in the field of food safety.
KW - Aflatoxins
KW - Competitive assay
KW - Food safety control
KW - Immunoassay
KW - Immunosensor
KW - Nanomaterial
UR - http://www.scopus.com/inward/record.url?scp=84958890571&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2016.01.048
DO - 10.1016/j.aca.2016.01.048
M3 - Review article
C2 - 26920768
AN - SCOPUS:84958890571
SN - 0003-2670
VL - 912
SP - 10
EP - 23
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
ER -