Nanoparticle-based immunosensors and immunoassays for aflatoxins

Xu Wang, Reinhard Niessner, Dianping Tang, Dietmar Knopp

Research output: Contribution to journalReview articlepeer-review

133 Scopus citations

Abstract

Aflatoxins are naturally existing mycotoxins produced mainly by Aspergillus flavus and Aspergillus parasiticus, present in a wide range of food and feed products. Because of their extremely high toxicity and carcinogenicity, strict control of maximum residue levels of aflatoxins in foodstuff is set by many countries. In daily routine, different chromatographic methods are used almost exclusively. As supplement, in several companies enzyme immunoassay-based sample testing as primary screening is performed. Recently, nanomaterials such as noble metal nanoparticles, magnetic particles, carbon nanomaterials, quantum dots, and silica nanomaterials are increasingly utilized for aflatoxin determination to improve the sensitivity and simplify the detection. They are employed either as supports for the immobilization of biomolecules or as electroactive or optical labels for signal transduction and amplification. Several nanoparticle-based electrochemical, piezoelectric, optical, and immunodipstick assays for aflatoxins have been developed. In this review, we summarize these recent advances and illustrate novel concepts and promising applications in the field of food safety.

Original languageEnglish
Pages (from-to)10-23
Number of pages14
JournalAnalytica Chimica Acta
Volume912
DOIs
StatePublished - 17 Mar 2016

Keywords

  • Aflatoxins
  • Competitive assay
  • Food safety control
  • Immunoassay
  • Immunosensor
  • Nanomaterial

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