Nano-coating protects biofunctional materials

Rupert Tscheliessnig; Martin Zörnig; Eva M. Herzig; Katharina Lückerath; Jens Altrichter; Kristina Kemter; Adnana Paunel-Görgülü; Tim Lögters; Joachim Windolf; Silvia Pabisch; Jindrich Cinatl; Holger F. Rabenau; Alois Jungbauer; Peter Müller-Buschbaum; Martin Scholz; Joachim Koch

doi:10.1016/S1369-7021(12)70166-9

Nano-coating protects biofunctional materials

Rupert Tscheliessnig
, Martin Zörnig
, Eva M. Herzig
, Katharina Lückerath
, Jens Altrichter
, Kristina Kemter
, Adnana Paunel-Görgülü
, Tim Lögters
, Joachim Windolf
, Silvia Pabisch
, Jindrich Cinatl
, Holger F. Rabenau
, Alois Jungbauer
, Peter Müller-Buschbaum
, Martin Scholz
, Joachim Koch

Chair of Functional Materials

University of Natural Resources and Applied Life Sciences
Austrian Centre of Industrial Biotechnology GmbH
Institute for Biomedical Research
Technical University of Munich
Leukocare AG
Heinrich-Heine-University
Vienna-UNI
Johann Wolfgang Goethe University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

Original language	English
Pages (from-to)	394-404
Number of pages	11
Journal	Materials Today
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/S1369-7021(12)70166-9
State	Published - Sep 2012

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Tscheliessnig, R., Zörnig, M., Herzig, E. M., Lückerath, K., Altrichter, J., Kemter, K., Paunel-Görgülü, A., Lögters, T., Windolf, J., Pabisch, S., Cinatl, J., Rabenau, H. F., Jungbauer, A., Müller-Buschbaum, P., Scholz, M., & Koch, J. (2012). Nano-coating protects biofunctional materials. Materials Today, 15(9), 394-404. https://doi.org/10.1016/S1369-7021(12)70166-9

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title = "Nano-coating protects biofunctional materials",

abstract = "The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.",

author = "Rupert Tscheliessnig and Martin Z{\"o}rnig and Herzig, \{Eva M.\} and Katharina L{\"u}ckerath and Jens Altrichter and Kristina Kemter and Adnana Paunel-G{\"o}rg{\"u}l{\"u} and Tim L{\"o}gters and Joachim Windolf and Silvia Pabisch and Jindrich Cinatl and Rabenau, \{Holger F.\} and Alois Jungbauer and Peter M{\"u}ller-Buschbaum and Martin Scholz and Joachim Koch",

note = "Funding Information: This study was supported by grants from the PRO INNO (Bundesministerium f{\"u}r Wirtschaft und Technologie; to A.P.-G.), Deutsche Forschungsgemeinschaft (SCHO 612/3-1 to M.S. and ZO 110/4-1 to M.Z.), Wilhelm Sander-Stiftung (2008.091.1 to M.Z.), LOEWE Center for Cell and Gene Therapy Frankfurt (Hessisches Ministerium f{\"u}r Wissenschaft und Kunst (HMWK); III L 4-518/17.004; 2010) (J.K.), and Bundesministerium f{\"u}r Bildung und Forschung.",

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doi = "10.1016/S1369-7021(12)70166-9",

language = "English",

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AU - Tscheliessnig, Rupert

AU - Zörnig, Martin

AU - Herzig, Eva M.

AU - Lückerath, Katharina

AU - Altrichter, Jens

AU - Kemter, Kristina

AU - Paunel-Görgülü, Adnana

AU - Lögters, Tim

AU - Windolf, Joachim

AU - Pabisch, Silvia

AU - Cinatl, Jindrich

AU - Rabenau, Holger F.

AU - Jungbauer, Alois

AU - Müller-Buschbaum, Peter

AU - Scholz, Martin

AU - Koch, Joachim

N1 - Funding Information: This study was supported by grants from the PRO INNO (Bundesministerium für Wirtschaft und Technologie; to A.P.-G.), Deutsche Forschungsgemeinschaft (SCHO 612/3-1 to M.S. and ZO 110/4-1 to M.Z.), Wilhelm Sander-Stiftung (2008.091.1 to M.Z.), LOEWE Center for Cell and Gene Therapy Frankfurt (Hessisches Ministerium für Wissenschaft und Kunst (HMWK); III L 4-518/17.004; 2010) (J.K.), and Bundesministerium für Bildung und Forschung.

PY - 2012/9

Y1 - 2012/9

N2 - The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

AB - The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

UR - https://www.scopus.com/pages/publications/84867387424

U2 - 10.1016/S1369-7021(12)70166-9

DO - 10.1016/S1369-7021(12)70166-9

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SN - 1369-7021

VL - 15

SP - 394

EP - 404

JO - Materials Today

JF - Materials Today

IS - 9

ER -

Nano-coating protects biofunctional materials

Abstract

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