Nano-coating protects biofunctional materials

Rupert Tscheliessnig; Martin Zörnig; Eva M. Herzig; Katharina Lückerath; Jens Altrichter; Kristina Kemter; Adnana Paunel-Görgülü; Tim Lögters; Joachim Windolf; Silvia Pabisch; Jindrich Cinatl; Holger F. Rabenau; Alois Jungbauer; Peter Müller-Buschbaum; Martin Scholz; Joachim Koch

doi:10.1016/S1369-7021(12)70166-9

Nano-coating protects biofunctional materials

Rupert Tscheliessnig, Martin Zörnig, Eva M. Herzig, Katharina Lückerath, Jens Altrichter, Kristina Kemter, Adnana Paunel-Görgülü, Tim Lögters, Joachim Windolf, Silvia Pabisch, Jindrich Cinatl, Holger F. Rabenau, Alois Jungbauer, Peter Müller-Buschbaum, Martin Scholz, Joachim Koch

Chair of Functional Materials

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

Original language	English
Pages (from-to)	394-404
Number of pages	11
Journal	Materials Today
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/S1369-7021(12)70166-9
State	Published - Sep 2012

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Tscheliessnig, R., Zörnig, M., Herzig, E. M., Lückerath, K., Altrichter, J., Kemter, K., Paunel-Görgülü, A., Lögters, T., Windolf, J., Pabisch, S., Cinatl, J., Rabenau, H. F., Jungbauer, A., Müller-Buschbaum, P., Scholz, M., & Koch, J. (2012). Nano-coating protects biofunctional materials. Materials Today, 15(9), 394-404. https://doi.org/10.1016/S1369-7021(12)70166-9

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title = "Nano-coating protects biofunctional materials",

abstract = "The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.",

author = "Rupert Tscheliessnig and Martin Z{\"o}rnig and Herzig, {Eva M.} and Katharina L{\"u}ckerath and Jens Altrichter and Kristina Kemter and Adnana Paunel-G{\"o}rg{\"u}l{\"u} and Tim L{\"o}gters and Joachim Windolf and Silvia Pabisch and Jindrich Cinatl and Rabenau, {Holger F.} and Alois Jungbauer and Peter M{\"u}ller-Buschbaum and Martin Scholz and Joachim Koch",

note = "Funding Information: This study was supported by grants from the PRO INNO (Bundesministerium f{\"u}r Wirtschaft und Technologie; to A.P.-G.), Deutsche Forschungsgemeinschaft (SCHO 612/3-1 to M.S. and ZO 110/4-1 to M.Z.), Wilhelm Sander-Stiftung (2008.091.1 to M.Z.), LOEWE Center for Cell and Gene Therapy Frankfurt (Hessisches Ministerium f{\"u}r Wissenschaft und Kunst (HMWK); III L 4-518/17.004; 2010) (J.K.), and Bundesministerium f{\"u}r Bildung und Forschung.",

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doi = "10.1016/S1369-7021(12)70166-9",

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AU - Zörnig, Martin

AU - Herzig, Eva M.

AU - Lückerath, Katharina

AU - Altrichter, Jens

AU - Kemter, Kristina

AU - Paunel-Görgülü, Adnana

AU - Lögters, Tim

AU - Windolf, Joachim

AU - Pabisch, Silvia

AU - Cinatl, Jindrich

AU - Rabenau, Holger F.

AU - Jungbauer, Alois

AU - Müller-Buschbaum, Peter

AU - Scholz, Martin

AU - Koch, Joachim

N1 - Funding Information: This study was supported by grants from the PRO INNO (Bundesministerium für Wirtschaft und Technologie; to A.P.-G.), Deutsche Forschungsgemeinschaft (SCHO 612/3-1 to M.S. and ZO 110/4-1 to M.Z.), Wilhelm Sander-Stiftung (2008.091.1 to M.Z.), LOEWE Center for Cell and Gene Therapy Frankfurt (Hessisches Ministerium für Wissenschaft und Kunst (HMWK); III L 4-518/17.004; 2010) (J.K.), and Bundesministerium für Bildung und Forschung.

PY - 2012/9

Y1 - 2012/9

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AB - The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

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Nano-coating protects biofunctional materials

Abstract

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