NADPH-Oxidasen und HIF: zentrale Elemente der Redoxhomöostase

Translated title of the contribution: NADPH oxidases and HIF: Central elements of redox homeostasis

Andreas Petry, Agnes Görlach

Research output: Contribution to journalComment/debate

Abstract

Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases are the sole enzymes to generate ROS playing an important role in redox signaling. They closely interact in several ways with hypoxia-inducible transcription factors of the HIF family. This signaling network is active under normoxic and hypoxic conditions as an important regulator of redox homeostasis. Members of the NADPH oxidases-HIF axis appear as interesting therapeutic targets for various disorders characterized by an impaired redox homeostasis.

Translated title of the contributionNADPH oxidases and HIF: Central elements of redox homeostasis
Original languageGerman
Pages (from-to)142-145
Number of pages4
JournalBioSpektrum
Volume27
Issue number2
DOIs
StatePublished - Mar 2021

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