N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer

Niels Teich; Hans Ulrich Schulz; Heiko Witt; Michael Böhmig; Volker Keim

doi:10.1159/000069145

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer

Niels Teich, Hans Ulrich Schulz, Heiko Witt, Michael Böhmig, Volker Keim

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer. Methods: The N34S allele of SPINK1 was analyzed by melting curve analysis using fluorescence resonance energy transfer (FRET) probes and the LightCycler in 159 German patients with sporadic pancreatic cancer (83 male, 76 female, median age of diagnosis 61 years, range 36-84 years) and 492 healthy controls. Results: The N34S mutation was detected in 2 (1.3%) of the 159 patients with pancreatic cancer and in 8 (1.6%) of the 492 controls (not significant). Conclusion: The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer.

Original language	English
Pages (from-to)	67-68
Number of pages	2
Journal	Pancreatology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1159/000069145
State	Published - 2003
Externally published	Yes

Keywords

Chronic pancreatitis
Mutation
Pancreatic cancer
SPINK1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000069145

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@article{ff6dcc955ac44a749697d173836025a7,

title = "N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer",

abstract = "Background: The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer. Methods: The N34S allele of SPINK1 was analyzed by melting curve analysis using fluorescence resonance energy transfer (FRET) probes and the LightCycler in 159 German patients with sporadic pancreatic cancer (83 male, 76 female, median age of diagnosis 61 years, range 36-84 years) and 492 healthy controls. Results: The N34S mutation was detected in 2 (1.3%) of the 159 patients with pancreatic cancer and in 8 (1.6%) of the 492 controls (not significant). Conclusion: The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer.",

keywords = "Chronic pancreatitis, Mutation, Pancreatic cancer, SPINK1",

author = "Niels Teich and Schulz, {Hans Ulrich} and Heiko Witt and Michael B{\"o}hmig and Volker Keim",

note = "Funding Information: We thank Christiane Jechorek (Magdeburg), Claudia G{\"u}ldner (Berlin) and Susanne Kistner (Leipzig) for expert technical assistance. This study was supported by a grant from the Sonnenfeld Stif-tung, Berlin, Germany.",

year = "2003",

doi = "10.1159/000069145",

language = "English",

volume = "3",

pages = "67--68",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer

AU - Teich, Niels

AU - Schulz, Hans Ulrich

AU - Witt, Heiko

AU - Böhmig, Michael

AU - Keim, Volker

N1 - Funding Information: We thank Christiane Jechorek (Magdeburg), Claudia Güldner (Berlin) and Susanne Kistner (Leipzig) for expert technical assistance. This study was supported by a grant from the Sonnenfeld Stif-tung, Berlin, Germany.

PY - 2003

Y1 - 2003

N2 - Background: The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer. Methods: The N34S allele of SPINK1 was analyzed by melting curve analysis using fluorescence resonance energy transfer (FRET) probes and the LightCycler in 159 German patients with sporadic pancreatic cancer (83 male, 76 female, median age of diagnosis 61 years, range 36-84 years) and 492 healthy controls. Results: The N34S mutation was detected in 2 (1.3%) of the 159 patients with pancreatic cancer and in 8 (1.6%) of the 492 controls (not significant). Conclusion: The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer.

AB - Background: The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer. Methods: The N34S allele of SPINK1 was analyzed by melting curve analysis using fluorescence resonance energy transfer (FRET) probes and the LightCycler in 159 German patients with sporadic pancreatic cancer (83 male, 76 female, median age of diagnosis 61 years, range 36-84 years) and 492 healthy controls. Results: The N34S mutation was detected in 2 (1.3%) of the 159 patients with pancreatic cancer and in 8 (1.6%) of the 492 controls (not significant). Conclusion: The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer.

KW - Chronic pancreatitis

KW - Mutation

KW - Pancreatic cancer

KW - SPINK1

UR - http://www.scopus.com/inward/record.url?scp=0037227423&partnerID=8YFLogxK

U2 - 10.1159/000069145

DO - 10.1159/000069145

M3 - Article

C2 - 12649567

AN - SCOPUS:0037227423

SN - 1424-3903

VL - 3

SP - 67

EP - 68

JO - Pancreatology

JF - Pancreatology

IS - 1

ER -

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer

Abstract

Keywords

UN SDGs

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