N-Glycyl-glucosamine: A novel constituent in the cell wall of Halococcus morrhuae

Josef Steber, Karl Heinz Schleifer

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The dinitrophenyl-derivative of N-glycylglucosamine was isolated from partially hydrolyzed dinitrophenylated cell walls of Halococcus morrhuae CCM 859. To increase the yield of amino-terminal glycine residues, halococcal cell walls were treated with alkali or acid prior to dinitrophenylation. Authentic N-glycyl-glucosamine was used as a reference substance. A substitution of the amino group of glucosamine by an amino acid has so far not been found in any other wall of a pro- or eucaryotic cell. Since only 5% of the glycine residues reveal an unsubstituted carboxyl group within intact cell walls, glycine may play a role in connecting glycan strands through peptidic linkages between the amino group of glucosamine and the carboxyl group of an uronic acid or gulosaminuronic acid.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalArchives of Microbiology
Issue number2
StatePublished - Nov 1979
Externally publishedYes


  • Archaebacteria
  • Cell wall
  • Hatococcus
  • N-Glycyl-glucosamine


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