Myeloid-derived suppressor cells in bacterial infections

Michael Ost; Anurag Singh; Andreas Peschel; Roman Mehling; Nikolaus Rieber; Dominik Hartl

doi:10.3389/fcimb.2016.00037

Myeloid-derived suppressor cells in bacterial infections

Michael Ost, Anurag Singh, Andreas Peschel, Roman Mehling, Nikolaus Rieber, Dominik Hartl

Department of Pediatric Medicine

University of Tübingen

Research output: Contribution to journal › Short survey › peer-review

102 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

Original language	English
Article number	37
Journal	Frontiers in Cellular and Infection Microbiology
Volume	6
Issue number	MAR
DOIs	https://doi.org/10.3389/fcimb.2016.00037
State	Published - 31 Mar 2016

Keywords

Bacteria
Immune suppression
Infection
MDSC
Myeloid-derived suppressor cells
Sepsis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fcimb.2016.00037

Cite this

@article{ed92529605b9422987a40394766012a2,

title = "Myeloid-derived suppressor cells in bacterial infections",

abstract = "Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.",

keywords = "Bacteria, Immune suppression, Infection, MDSC, Myeloid-derived suppressor cells, Sepsis",

author = "Michael Ost and Anurag Singh and Andreas Peschel and Roman Mehling and Nikolaus Rieber and Dominik Hartl",

note = "Publisher Copyright: {\textcopyright} 2016 Ost, Singh, Peschel, Mehling, Rieber and Hartl.",

year = "2016",

month = mar,

day = "31",

doi = "10.3389/fcimb.2016.00037",

language = "English",

volume = "6",

journal = "Frontiers in Cellular and Infection Microbiology",

issn = "2235-2988",

publisher = "Frontiers Media SA",

number = "MAR",

}

TY - JOUR

T1 - Myeloid-derived suppressor cells in bacterial infections

AU - Ost, Michael

AU - Singh, Anurag

AU - Peschel, Andreas

AU - Mehling, Roman

AU - Rieber, Nikolaus

AU - Hartl, Dominik

PY - 2016/3/31

Y1 - 2016/3/31

N2 - Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

AB - Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

KW - Bacteria

KW - Immune suppression

KW - Infection

KW - MDSC

KW - Myeloid-derived suppressor cells

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=85006200850&partnerID=8YFLogxK

U2 - 10.3389/fcimb.2016.00037

DO - 10.3389/fcimb.2016.00037

M3 - Short survey

C2 - 27066459

AN - SCOPUS:85006200850

SN - 2235-2988

VL - 6

JO - Frontiers in Cellular and Infection Microbiology

JF - Frontiers in Cellular and Infection Microbiology

IS - MAR

M1 - 37

ER -

Myeloid-derived suppressor cells in bacterial infections

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this