Myeloid-derived suppressor cells in bacterial infections

Michael Ost, Anurag Singh, Andreas Peschel, Roman Mehling, Nikolaus Rieber, Dominik Hartl

Research output: Contribution to journalShort surveypeer-review

94 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

Original languageEnglish
Article number37
JournalFrontiers in Cellular and Infection Microbiology
Volume6
Issue numberMAR
DOIs
StatePublished - 31 Mar 2016
Externally publishedYes

Keywords

  • Bacteria
  • Immune suppression
  • Infection
  • MDSC
  • Myeloid-derived suppressor cells
  • Sepsis

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