Myeloid cell-based therapies in neurological disorders: How far have we come?

Chotima Böttcher, Josef Priller

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The pathogenesis of neurological disorders such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) is multifactorial and incompletely understood. The development of therapies for these disorders of the central nervous system (CNS) is thus far very challenging. Neuroinflammation is one of the processes that contribute to the pathogenesis of CNS diseases, and therefore represents an important therapeutic target. Myeloid cells derived from the bone marrow are ideal candidates for cell therapy in the CNS as they are capable of targeting the brain and providing neuroprotective and anti-inflammatory effects. In this review, experimental and clinical evidence for the therapeutic potential of myeloid cells in neurological disorders will be discussed. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number3
StatePublished - 1 Mar 2016
Externally publishedYes


  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Bone marrow
  • Multiple sclerosis
  • Neurodegeneration
  • Neuroinflammation
  • Stem cells


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