Myelination at a glance

Nicolas Snaidero, Mikael Simons

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

The myelin sheath is a plasma membrane extension that is laid down in regularly spaced segments along axons of the nervous system. This process involves extensive changes in oligodendrocyte cell shape and membrane architecture. In this Cell Science at a Glance article and accompanying poster, we provide a model of how myelin of the central nervous system is wrapped around axons to form a tightly compacted, multilayered membrane structure. This model may not only explain how myelin is generated during brain development, but could also help us to understand myelin remodeling in adult life, which might serve as a form of plasticity for the fine-tuning of neuronal networks.

Original languageEnglish
Pages (from-to)2999-3004
Number of pages6
JournalJournal of Cell Science
Volume127
Issue number14
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Axons
  • Central nervous system
  • Myelin
  • Neurons
  • Oligodendrocytes

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