Mutual antagonism of T cells causing psoriasis and atopic eczema

Stefanie Eyerich; Anna T. Onken; Stephan Weidinger; Andre Franke; Francesca Nasorri; Davide Pennino; Martine Grosber; Florian Pfab; Carsten B. Schmidt-Weber; Martin Mempel; Ruediger Hein; Johannes Ring; Andrea Cavani; Kilian Eyerich

doi:10.1056/NEJMoa1104200

Mutual antagonism of T cells causing psoriasis and atopic eczema

Stefanie Eyerich
, Anna T. Onken
, Stephan Weidinger
, Andre Franke
, Francesca Nasorri
, Davide Pennino
, Martine Grosber
, Florian Pfab
, Carsten B. Schmidt-Weber
, Martin Mempel
, Ruediger Hein
, Johannes Ring
, Andrea Cavani
, Kilian Eyerich

Helmholtz Zentrum München German Research Center for Environmental Health
Technical University of Munich
University Hospital Schleswig-Holstein
IDI-IRCCS
University Medical Center

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

Original language	English
Pages (from-to)	231-238
Number of pages	8
Journal	New England Journal of Medicine
Volume	365
Issue number	3
DOIs	https://doi.org/10.1056/NEJMoa1104200
State	Published - 21 Jul 2011

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title = "Mutual antagonism of T cells causing psoriasis and atopic eczema",

abstract = "The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.",

author = "Stefanie Eyerich and Onken, \{Anna T.\} and Stephan Weidinger and Andre Franke and Francesca Nasorri and Davide Pennino and Martine Grosber and Florian Pfab and Schmidt-Weber, \{Carsten B.\} and Martin Mempel and Ruediger Hein and Johannes Ring and Andrea Cavani and Kilian Eyerich",

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doi = "10.1056/NEJMoa1104200",

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T1 - Mutual antagonism of T cells causing psoriasis and atopic eczema

AU - Eyerich, Stefanie

AU - Onken, Anna T.

AU - Weidinger, Stephan

AU - Franke, Andre

AU - Nasorri, Francesca

AU - Pennino, Davide

AU - Grosber, Martine

AU - Pfab, Florian

AU - Schmidt-Weber, Carsten B.

AU - Mempel, Martin

AU - Hein, Ruediger

AU - Ring, Johannes

AU - Cavani, Andrea

AU - Eyerich, Kilian

PY - 2011/7/21

Y1 - 2011/7/21

N2 - The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

AB - The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

UR - https://www.scopus.com/pages/publications/79960578839

U2 - 10.1056/NEJMoa1104200

DO - 10.1056/NEJMoa1104200

M3 - Article

AN - SCOPUS:79960578839

SN - 0028-4793

VL - 365

SP - 231

EP - 238

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 3

ER -

Mutual antagonism of T cells causing psoriasis and atopic eczema

Abstract

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