Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

Daniel Razansky; Niels J. Harlaar; Jan Luuk Hillebrands; Adrian Taruttis; Eva Herzog; Clark Zeebregts; Goitzen Van Dam; Vasilis Ntziachristos

doi:10.1117/12.875271

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

Daniel Razansky, Niels J. Harlaar, Jan Luuk Hillebrands, Adrian Taruttis, Eva Herzog, Clark Zeebregts, Goitzen Van Dam, Vasilis Ntziachristos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2011
DOIs	https://doi.org/10.1117/12.875271
State	Published - 2011
Event	Photons Plus Ultrasound: Imaging and Sensing 2011 - San Francisco, CA, United States Duration: 23 Jan 2011 → 25 Jan 2011

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7899
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2011
Country/Territory	United States
City	San Francisco, CA
Period	23/01/11 → 25/01/11

Keywords

Atherosclerosis
Carotid plaques
Molecular imaging
Multispectral optoacoustic tomography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.875271

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Razansky, D., Harlaar, N. J., Hillebrands, J. L., Taruttis, A., Herzog, E., Zeebregts, C., Van Dam, G., & Ntziachristos, V. (2011). Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques. In Photons Plus Ultrasound: Imaging and Sensing 2011 Article 789905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7899). https://doi.org/10.1117/12.875271

@inproceedings{51136fffad8644ba953d7321d41e3427,

title = "Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques",

abstract = "In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.",

keywords = "Atherosclerosis, Carotid plaques, Molecular imaging, Multispectral optoacoustic tomography",

author = "Daniel Razansky and Harlaar, {Niels J.} and Hillebrands, {Jan Luuk} and Adrian Taruttis and Eva Herzog and Clark Zeebregts and {Van Dam}, Goitzen and Vasilis Ntziachristos",

year = "2011",

doi = "10.1117/12.875271",

language = "English",

isbn = "9780819484369",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Photons Plus Ultrasound",

note = "Photons Plus Ultrasound: Imaging and Sensing 2011 ; Conference date: 23-01-2011 Through 25-01-2011",

}

Razansky, D, Harlaar, NJ, Hillebrands, JL, Taruttis, A, Herzog, E, Zeebregts, C, Van Dam, G & Ntziachristos, V 2011, Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques. in Photons Plus Ultrasound: Imaging and Sensing 2011., 789905, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, San Francisco, CA, United States, 23/01/11. https://doi.org/10.1117/12.875271

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques. / Razansky, Daniel; Harlaar, Niels J.; Hillebrands, Jan Luuk et al.
Photons Plus Ultrasound: Imaging and Sensing 2011. 2011. 789905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7899).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

AU - Razansky, Daniel

AU - Harlaar, Niels J.

AU - Hillebrands, Jan Luuk

AU - Taruttis, Adrian

AU - Herzog, Eva

AU - Zeebregts, Clark

AU - Van Dam, Goitzen

AU - Ntziachristos, Vasilis

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N2 - In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

AB - In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

KW - Atherosclerosis

KW - Carotid plaques

KW - Molecular imaging

KW - Multispectral optoacoustic tomography

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M3 - Conference contribution

AN - SCOPUS:79955519991

SN - 9780819484369

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

T2 - Photons Plus Ultrasound: Imaging and Sensing 2011

Y2 - 23 January 2011 through 25 January 2011

ER -

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

Abstract

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Keywords

UN SDGs

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