TY - CHAP
T1 - Multispectral optoacoustic tomography of brown adipose tissue
AU - Karlas, Angelos
AU - Reber, Josefine
AU - Liapis, Evangelos
AU - Paul-Yuan, Korbinian
AU - Ntziachristos, Vasilis
N1 - Publisher Copyright:
© Springer International Publishing AG, part of Springer Nature 2018.
PY - 2019
Y1 - 2019
N2 - MSOT has revolutionized biomedical imaging because it allows anatomical, functional, and molecular imaging of deep tissues in vivo in an entirely noninvasive, label-free, and real-time manner. This imaging modality works by pulsing light onto tissue, triggering the production of acoustic waves, which can be collected and reconstructed to provide high-resolution images of features as deep as several centimeters below the body surface. Advances in hardware and software continue to bring MSOT closer to clinical translation. Most recently, a clinical handheld MSOT system has been used to image brown fat tissue (BAT) and its metabolic activity by directly resolving the spectral signatures of hemoglobin and lipids. This opens up new possibilities for studying BAT physiology and its role in metabolic disease without the need to inject animals or humans with contrast agents. In this chapter, we overview how MSOT works and how it has been implemented in preclinical and clinical contexts. We focus on our recent work using MSOT to image BAT in resting and activated states both in mice and humans.
AB - MSOT has revolutionized biomedical imaging because it allows anatomical, functional, and molecular imaging of deep tissues in vivo in an entirely noninvasive, label-free, and real-time manner. This imaging modality works by pulsing light onto tissue, triggering the production of acoustic waves, which can be collected and reconstructed to provide high-resolution images of features as deep as several centimeters below the body surface. Advances in hardware and software continue to bring MSOT closer to clinical translation. Most recently, a clinical handheld MSOT system has been used to image brown fat tissue (BAT) and its metabolic activity by directly resolving the spectral signatures of hemoglobin and lipids. This opens up new possibilities for studying BAT physiology and its role in metabolic disease without the need to inject animals or humans with contrast agents. In this chapter, we overview how MSOT works and how it has been implemented in preclinical and clinical contexts. We focus on our recent work using MSOT to image BAT in resting and activated states both in mice and humans.
KW - Brown adipose tissue
KW - Hemoglobin oxygenation
KW - MSOT
KW - Metabolic imaging
KW - Optoacoustics
KW - Photoacoustics
KW - Spectral unmixing
UR - http://www.scopus.com/inward/record.url?scp=85058561093&partnerID=8YFLogxK
U2 - 10.1007/164_2018_141
DO - 10.1007/164_2018_141
M3 - Chapter
C2 - 29896652
AN - SCOPUS:85058561093
T3 - Handbook of Experimental Pharmacology
SP - 325
EP - 336
BT - Handbook of Experimental Pharmacology
PB - Springer New York LLC
ER -