Multispectral optoacoustic tomography by means of normalized spectral ratio

Thomas Jetzfellner; Amir Rosenthal; Andreas Buehler; Karl Hans Englmeier; Daniel Razansky; Vasilis Ntziachristos

doi:10.1364/OL.36.004176

Multispectral optoacoustic tomography by means of normalized spectral ratio

Thomas Jetzfellner
, Amir Rosenthal
, Andreas Buehler
, Karl Hans Englmeier
, Daniel Razansky
, Vasilis Ntziachristos

Helmholtz Zentrum München German Research Center for Environmental Health

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.

Original language	English
Pages (from-to)	4176-4178
Number of pages	3
Journal	Optics Letters
Volume	36
Issue number	21
DOIs	https://doi.org/10.1364/OL.36.004176
State	Published - 1 Nov 2011
Externally published	Yes

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10.1364/OL.36.004176

Cite this

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title = "Multispectral optoacoustic tomography by means of normalized spectral ratio",

abstract = "Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.",

author = "Thomas Jetzfellner and Amir Rosenthal and Andreas Buehler and Englmeier, \{Karl Hans\} and Daniel Razansky and Vasilis Ntziachristos",

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AU - Jetzfellner, Thomas

AU - Rosenthal, Amir

AU - Buehler, Andreas

AU - Englmeier, Karl Hans

AU - Razansky, Daniel

AU - Ntziachristos, Vasilis

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.

AB - Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.

UR - https://www.scopus.com/pages/publications/80455132225

U2 - 10.1364/OL.36.004176

DO - 10.1364/OL.36.004176

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EP - 4178

JO - Optics Letters

JF - Optics Letters

IS - 21

ER -

Multispectral optoacoustic tomography by means of normalized spectral ratio

Abstract

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