Multiple simian virus 40 enhancer elements mediate the trans-activating function of the X protein of hepatitis B virus

Birgit Luber; Elisabeth Bürgelt; Catherine Fromental; Masamoto Kanno; Werner Koch

doi:10.1016/0042-6822(91)90458-N

Multiple simian virus 40 enhancer elements mediate the trans-activating function of the X protein of hepatitis B virus

Birgit Luber, Elisabeth Bürgelt, Catherine Fromental, Masamoto Kanno, Werner Koch

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Transient transfections of tissue culture cells with plasmids encoding the X protein of hepatitis B virus result in a transcriptional trans-activation of certain target genes. Our experiments reveal that several individual simian virus 40 enhancer elements and a control element present in the mouse major histocompatibility class I gene H-2K^b are able to mediate the trans-activating function of the X protein. The data suggest that known cellular transcription factors that bind specifically to the multiple enhancer elements participate in trans-activation.

Original language	English
Pages (from-to)	808-813
Number of pages	6
Journal	Virology
Volume	184
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(91)90458-N
State	Published - Oct 1991
Externally published	Yes

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title = "Multiple simian virus 40 enhancer elements mediate the trans-activating function of the X protein of hepatitis B virus",

abstract = "Transient transfections of tissue culture cells with plasmids encoding the X protein of hepatitis B virus result in a transcriptional trans-activation of certain target genes. Our experiments reveal that several individual simian virus 40 enhancer elements and a control element present in the mouse major histocompatibility class I gene H-2Kb are able to mediate the trans-activating function of the X protein. The data suggest that known cellular transcription factors that bind specifically to the multiple enhancer elements participate in trans-activation.",

author = "Birgit Luber and Elisabeth B{\"u}rgelt and Catherine Fromental and Masamoto Kanno and Werner Koch",

note = "Funding Information: We thank knowledge to perform Biochemie. Stiftung ftir R. Koshy for plasmids and cell lines and gratefully the generous support of P. H. Hofschneider enabling this study in his department at the Max-Planck-lnstitut This work was supported by funds from the Deutsche Krebsforschung awarded to P. H. Hofschneider.",

year = "1991",

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doi = "10.1016/0042-6822(91)90458-N",

language = "English",

volume = "184",

pages = "808--813",

journal = "Virology",

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T1 - Multiple simian virus 40 enhancer elements mediate the trans-activating function of the X protein of hepatitis B virus

AU - Luber, Birgit

AU - Bürgelt, Elisabeth

AU - Fromental, Catherine

AU - Kanno, Masamoto

AU - Koch, Werner

N1 - Funding Information: We thank knowledge to perform Biochemie. Stiftung ftir R. Koshy for plasmids and cell lines and gratefully the generous support of P. H. Hofschneider enabling this study in his department at the Max-Planck-lnstitut This work was supported by funds from the Deutsche Krebsforschung awarded to P. H. Hofschneider.

PY - 1991/10

Y1 - 1991/10

N2 - Transient transfections of tissue culture cells with plasmids encoding the X protein of hepatitis B virus result in a transcriptional trans-activation of certain target genes. Our experiments reveal that several individual simian virus 40 enhancer elements and a control element present in the mouse major histocompatibility class I gene H-2Kb are able to mediate the trans-activating function of the X protein. The data suggest that known cellular transcription factors that bind specifically to the multiple enhancer elements participate in trans-activation.

AB - Transient transfections of tissue culture cells with plasmids encoding the X protein of hepatitis B virus result in a transcriptional trans-activation of certain target genes. Our experiments reveal that several individual simian virus 40 enhancer elements and a control element present in the mouse major histocompatibility class I gene H-2Kb are able to mediate the trans-activating function of the X protein. The data suggest that known cellular transcription factors that bind specifically to the multiple enhancer elements participate in trans-activation.

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DO - 10.1016/0042-6822(91)90458-N

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C2 - 1653503

AN - SCOPUS:0025945618

SN - 0042-6822

VL - 184

SP - 808

EP - 813

JO - Virology

JF - Virology

IS - 2

ER -

Multiple simian virus 40 enhancer elements mediate the trans-activating function of the X protein of hepatitis B virus

Abstract

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