Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant

Keyphrases

• Gene Variants 100%
• Chemotherapy 100%
• 5-fluorouracil (5-FU) 100%
• Dihydropyrimidine Dehydrogenase 100%
• Multiple Organ Failure 100%
• Polymorphism 80%
• DPYD Gene 40%
• Metabolism 20%
• Direct Sequencing 20%
• Renal Function 20%
• Clinical Significance 20%
• Seizure 20%
• Exon 20%
• Myoclonus 20%
• Skipping mutations 20%
• Enzyme Activity 20%
• Dihydropyrimidine Dehydrogenase Deficiency 20%
• Protein Sequence 20%
• Multiple Organ Dysfunction 20%
• Severe Toxicity 20%
• Caecum 20%
• Folinic Acid 20%
• Bolus Injection 20%
• Left Ventricular Function 20%
• Intronic mutation 20%
• Narrow Therapeutic Index 20%
• Cardiogenic Shock 20%
• Somnolence 20%
• Hepatic Encephalopathy 20%
• Rate-limiting Enzyme 20%
• WHO Grade III 20%
• Exon 14 Skipping 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Chemotherapy 100%
• Multiple Organ Failure 100%
• Dihydropyrimidine Dehydrogenase 100%
• Fluorouracil 100%
• Antiinfective Agent 20%
• Therapeutic Window 20%
• Folinic Acid 20%
• Dihydropyrimidine Dehydrogenase Deficiency 20%
• Somnolence 20%
• Cardiogenic Shock 20%
• Hepatic Encephalopathy 20%
• Myoclonus 20%
• Cecum Cancer 20%
• Heart Ventricle Failure 20%

Biochemistry, Genetics and Molecular Biology

• Fluorouracil 100%
• Dihydropyrimidine Dehydrogenase 100%
• Exon 40%
• Digital Positive Youth Development 40%
• Metabolic Pathway 20%
• Genotyping 20%
• Peptide Sequence 20%
• Enzyme 20%
• Kidney Function 20%
• Enzyme Activity 20%
• Somnolence 20%
• Deficiency 20%