MULTIPLE ENDOKRINE NEOPLASIE TYP 1 (MEN 1). MOLEKULARGENETIK, MORPHOLOGIE UND PROGNOSE

S. Schroder; B. Padberg; C. Capella; A. Frilling; G. Kloppel; P. U. Heitz

doi:10.1007/s002920050038

MULTIPLE ENDOKRINE NEOPLASIE TYP 1 (MEN 1). MOLEKULARGENETIK, MORPHOLOGIE UND PROGNOSE

Translated title of the contribution: Multiple endocrine neoplasms type 1 (MEN 1). Molecular genetics, morphology and prognosis

S. Schroder, B. Padberg, C. Capella, A. Frilling, G. Kloppel, P. U. Heitz

University of Zurich

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The syndrome of multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant tumour disease of the neuroendocrine system with manifestations in the parathyroids, pancreas, duodenum and pituitary gland and rarely also in the stomach and thymus. Recently, the MEN 1 gene locus has been mapped to the long arm of chromosome 11. This gene most likely belongs to the tumour suppressor genes, the allelic loss of which causes tumour development. The pancreatic and duodenal tumours may metastasize, but usually have a low malignant potential. Clinically, most MEN 1 patients present between the age of 20 and 35 with hyperparathyroidism and/or Zollinger-Ellison syndrome.

Translated title of the contribution	Multiple endocrine neoplasms type 1 (MEN 1). Molecular genetics, morphology and prognosis
Original language	German
Pages (from-to)	150-157
Number of pages	8
Journal	Pathologe
Volume	15
Issue number	3
DOIs	https://doi.org/10.1007/s002920050038
State	Published - 1994
Externally published	Yes

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title = "MULTIPLE ENDOKRINE NEOPLASIE TYP 1 (MEN 1). MOLEKULARGENETIK, MORPHOLOGIE UND PROGNOSE",

abstract = "The syndrome of multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant tumour disease of the neuroendocrine system with manifestations in the parathyroids, pancreas, duodenum and pituitary gland and rarely also in the stomach and thymus. Recently, the MEN 1 gene locus has been mapped to the long arm of chromosome 11. This gene most likely belongs to the tumour suppressor genes, the allelic loss of which causes tumour development. The pancreatic and duodenal tumours may metastasize, but usually have a low malignant potential. Clinically, most MEN 1 patients present between the age of 20 and 35 with hyperparathyroidism and/or Zollinger-Ellison syndrome.",

keywords = "endocrine pancreatic tumours, gastrinomas, hyperparathyroidism, multiple endocrine neoplasias, parathyroid gland hyperplasia, pituitary adenomas",

author = "S. Schroder and B. Padberg and C. Capella and A. Frilling and G. Kloppel and Heitz, {P. U.}",

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T1 - MULTIPLE ENDOKRINE NEOPLASIE TYP 1 (MEN 1). MOLEKULARGENETIK, MORPHOLOGIE UND PROGNOSE

AU - Schroder, S.

AU - Padberg, B.

AU - Capella, C.

AU - Frilling, A.

AU - Kloppel, G.

AU - Heitz, P. U.

PY - 1994

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AB - The syndrome of multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant tumour disease of the neuroendocrine system with manifestations in the parathyroids, pancreas, duodenum and pituitary gland and rarely also in the stomach and thymus. Recently, the MEN 1 gene locus has been mapped to the long arm of chromosome 11. This gene most likely belongs to the tumour suppressor genes, the allelic loss of which causes tumour development. The pancreatic and duodenal tumours may metastasize, but usually have a low malignant potential. Clinically, most MEN 1 patients present between the age of 20 and 35 with hyperparathyroidism and/or Zollinger-Ellison syndrome.

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KW - gastrinomas

KW - hyperparathyroidism

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KW - parathyroid gland hyperplasia

KW - pituitary adenomas

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MULTIPLE ENDOKRINE NEOPLASIE TYP 1 (MEN 1). MOLEKULARGENETIK, MORPHOLOGIE UND PROGNOSE

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