Multinuclear NMR and MRI reveal an early metabolic response to mTOR inhibition in sarcoma

Keyphrases

• Multinuclear NMR 100%
• Sarcoma 100%
• MTOR Inhibitor 100%
• PI3K-AKT-mTOR Pathway 100%
• Early Metabolic Response 100%
• Multinuclear MRI 100%
• Lactate Production 66%
• Hyperpolarized MRI 66%
• Drug-induced 33%
• Clinical Trials 33%
• Cell Proliferation 33%
• Metabolic Changes 33%
• Pathway Activation 33%
• In Cancer 33%
• Monitoring Strategy 33%
• Driving Energy 33%
• Cancer Cells 33%
• Non-invasive Imaging 33%
• Reduced Cell 33%
• Energy Production 33%
• Cell Death 33%
• Phosphoinositide 3-kinase (PI3K) 33%
• Glycolysis 33%
• Sarcoma Cells 33%
• Phenotypic Effects 33%
• Anaerobic Glycolysis 33%
• Mammalian Target of Rapamycin (mTOR) 33%
• Cell Growth Inhibition 33%
• Multimodality Approach 33%
• Rapamycin Treatment 33%
• Human Sarcoma 33%
• Tumor Size Change 33%
• Rapalogs 33%
• Quantitative Reduction 33%

Medicine and Dentistry

• Magnetic Resonance Imaging 100%
• Metabolism 100%
• Mammalian Target of Rapamycin 100%
• NMR Spectroscopy 100%
• Connective Tissue Cancer 100%
• Lactic Acid 40%
• Biological Marker 20%
• Neoplasm 20%
• Clinical Trial 20%
• Cell Proliferation 20%
• Cell Growth 20%
• Drive 20%
• Cancer Cell 20%
• Anaerobic Glycolysis 20%
• In Vitro Production 20%
• Rapamycin 20%
• Growth Inhibition 20%
• Sarcoma Cell Line 20%
• Cell Death 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Connective Tissue Cancer 100%
• Lactic Acid 40%
• Clinical Trial 20%
• Malignant Neoplasm 20%
• Biological Marker 20%
• Neoplasm 20%
• Rapamycin 20%