Multimodal imaging in acute retinal ischemia: Spectral domain OCT, OCT-angiography and fundus autofluorescence

Nikolaus Feucht, Daniel Zapp, Lukas Reznicek, Chris P. Lohmann, Mathias Maier, Christian S. Mayer

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


AIM: To describe retinal findings of various imaging modalities in acute retinal ischemia. ● METHODS: Fluorescein angiography (FA), spectral domain optical coherence tomography (SD-OCT), OCT-angiography (OCT-A) and fundus autofluorescence (FAF) images of 13 patients (mean age 64y, range 28-86y) with acute retinal ischemia were evaluated. Six suffered from branch arterial occlusion, 2 had a central retinal artery occlusion, 2 had a combined arteriovenous occlusions, 1 patient had a retrobulbar arterial compression by an orbital haemangioma and 2 patients showed an ocular ischemic syndrome. ● RESULTS: All patients showed increased reflectivity and thickening of the ischemic retinal tissue. In 10 out of 13 patients SD-OCT revealed an additional highly reflective band located within or above the outer plexiform layer. Morphological characteristics were a decreasing intensity with distance from the fovea, partially segmental occurrence and manifestation limited in time. OCT-A showed a loss of flow signal in the superficial and deep capillary plexus at the affected areas. Reduced flow signal was detected underneath the regions with retinal edema. FAF showed areas of altered signal intensity at the posterior pole. The regions of decreased FAF signal corresponded to peri-venous regions. ● CONCLUSION: Multimodal imaging modalities in retinal ischemia yield characteristic findings and valuable diagnostic information. Conventional OCT identifies hyperreflectivity and thickening and a mid-retinal hyperreflective band is frequently observed. OCT-A examination reveals demarcation of the ischemic retinal area on the vascular level. FAF shows decreased fluorescence signal in areas of retinal edema often corresponding to peri-venous regions.

Original languageEnglish
Pages (from-to)1521-1527
Number of pages7
JournalInternational Journal of Ophthalmology
Issue number9
StatePublished - 2018


  • Acute retinal ischemia
  • Multimodal retinal imaging
  • Optical coherence tomography
  • Optical coherence tomography-angiography
  • Retinal blood flow
  • Retinal morphology


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