Multicomponent coupling reactions for organic synthesis: Chemoselective reactions with amide-aldehyde mixtures

Axel Jacobi Von Wangelin, Helfried Neumann, Dirk Gördes, Stefan Klaus, Dirk Strübing, Matthias Beller

Research output: Contribution to journalReview articlepeer-review

246 Scopus citations

Abstract

The acid-catalyzed condensation chemistry of simple amides and aldehydes provides a highly prolific source of diverse reactants for irreversible follow-up reactions. Amide-aldehyde mixtures have been successfully employed in multicomponent syntheses of N-acyl α-amino acids (via palladium-catalyzed amidocarbonylation) and various cyclohexene, cyclohexadiene, and benzene derivatives (via the amide-aldehyde-dienophile (AAD) reaction).

Original languageEnglish
Pages (from-to)4286-4294
Number of pages9
JournalChemistry - A European Journal
Volume9
Issue number18
DOIs
StatePublished - 22 Sep 2003
Externally publishedYes

Keywords

  • Amidocarbonylation
  • Diels-Alder reactions
  • Domino reactions
  • Multicomponent reactions

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