Multi-scale optoacoustic molecular imaging of brain diseases

Daniel Razansky, Jan Klohs, Ruiqing Ni

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The ability to non-invasively visualize endogenous chromophores and exogenous probes and sensors across the entire rodent brain with the high spatial and temporal resolution has empowered optoacoustic imaging modalities with unprecedented capacities for interrogating the brain under physiological and diseased conditions. This has rapidly transformed optoacoustic microscopy (OAM) and multi-spectral optoacoustic tomography (MSOT) into emerging research tools to study animal models of brain diseases. In this review, we describe the principles of optoacoustic imaging and showcase recent technical advances that enable high-resolution real-time brain observations in preclinical models. In addition, advanced molecular probe designs allow for efficient visualization of pathophysiological processes playing a central role in a variety of neurodegenerative diseases, brain tumors, and stroke. We describe outstanding challenges in optoacoustic imaging methodologies and propose a future outlook.

Original languageEnglish
Pages (from-to)4152-4170
Number of pages19
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume48
Issue number13
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • Brain
  • Multi-spectral optoacoustic tomography (MSOT)
  • Neuroimaging
  • Optical imaging
  • Photoacoustics

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