@article{2595725401274e66996efa59a28c4c2b,
title = "Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation",
abstract = "We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10−9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background.",
author = "FinnGen and {eMERGE Consortium} and Anubha Mahajan and Spracklen, {Cassandra N.} and Weihua Zhang and Ng, {Maggie C.Y.} and Petty, {Lauren E.} and Hidetoshi Kitajima and Yu, {Grace Z.} and Sina R{\"u}eger and Leo Speidel and Kim, {Young Jin} and Momoko Horikoshi and Mercader, {Josep M.} and Daniel Taliun and Sanghoon Moon and Kwak, {Soo Heon} and Robertson, {Neil R.} and Rayner, {Nigel W.} and Marie Loh and Kim, {Bong Jo} and Joshua Chiou and Irene Miguel-Escalada and {della Briotta Parolo}, Pietro and Kuang Lin and Fiona Bragg and Preuss, {Michael H.} and Fumihiko Takeuchi and Jana Nano and Xiuqing Guo and Amel Lamri and Masahiro Nakatochi and Scott, {Robert A.} and Lee, {Jung Jin} and Alicia Huerta-Chagoya and Mariaelisa Graff and Chai, {Jin Fang} and Parra, {Esteban J.} and Jie Yao and Bielak, {Lawrence F.} and Yasuharu Tabara and Yang Hai and Valgerdur Steinthorsdottir and Cook, {James P.} and Mart Kals and Niels Grarup and Schmidt, {Ellen M.} and Ian Pan and Tamar Sofer and Matthias Wuttke and Thomas Meitinger and Eleftheria Zeggini",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2022",
month = may,
day = "1",
doi = "10.1038/s41588-022-01058-3",
language = "English",
volume = "54",
pages = "560--572",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "5",
}