TY - JOUR
T1 - MRT der arthritis mit dem USPIO SH U 555 C
T2 - Optimierung des T1-enhancements
AU - Simon, Gerhard
AU - Daldrup-Link, H.
AU - Von Vopelius-Feldt, J.
AU - Wendland, M.
AU - Fu, Y.
AU - Schlegel, J.
AU - Rummeny, E.
PY - 2006/2
Y1 - 2006/2
N2 - Purpose: To optimize contrast agent dose and pulse sequence parameters in order to achieve a maximal T1 enhancement in arthritic knee joints with ultra small superparamagnetic iron oxides (USPIO)-enhanced MRI. Materials and Methods: Antigen-mediated arthritis was induced in the right knee of nine Sprague Dawley rats. The arthritic knee joint as well as the contralateral normal knee were investigated in a 2 Tesla MR scanner before as well as in short intervals up to 2 h after USPIO injection, using T1-weighted gradient echo (GE) sequences. Three rats each received intravenous injections of the new USPIO SHU 555 C (SH U 555 C, Schering AG, Berlin) at doses of 40,100 and 200 μmol Fe/kg. Pulse sequence parameters of the GE-sequence were optimized by varying flip angles (a) and echo times (TE). Changes in signal intensities (SI) of the arthritic knee and contralateral normal knee were quantified as ΔSI(%) = [([SIpost - SIpre]/SIpre) × 100%] and compared with histopathology. Results: Histology of the arthritic knees demonstrated a marked inflammatory proliferation of the synovium. The USPIO SH U 555 C caused a significant increase in signal intensity of the arthritic joints on T1-weighted MR images (p < 0.05). This effect was optimized using a flip angle of 60 - 70°, a minimal TE and a dose of 200 μmol Fe/kg. Visually the contralateral normal knee did not show any USPIO enhancement. Conclusion: Inflammation can be depicted with marked T1 enhancement by the USPIO SH U 555 C using high contrast agent doses and optimized MR pulse sequence parameters.
AB - Purpose: To optimize contrast agent dose and pulse sequence parameters in order to achieve a maximal T1 enhancement in arthritic knee joints with ultra small superparamagnetic iron oxides (USPIO)-enhanced MRI. Materials and Methods: Antigen-mediated arthritis was induced in the right knee of nine Sprague Dawley rats. The arthritic knee joint as well as the contralateral normal knee were investigated in a 2 Tesla MR scanner before as well as in short intervals up to 2 h after USPIO injection, using T1-weighted gradient echo (GE) sequences. Three rats each received intravenous injections of the new USPIO SHU 555 C (SH U 555 C, Schering AG, Berlin) at doses of 40,100 and 200 μmol Fe/kg. Pulse sequence parameters of the GE-sequence were optimized by varying flip angles (a) and echo times (TE). Changes in signal intensities (SI) of the arthritic knee and contralateral normal knee were quantified as ΔSI(%) = [([SIpost - SIpre]/SIpre) × 100%] and compared with histopathology. Results: Histology of the arthritic knees demonstrated a marked inflammatory proliferation of the synovium. The USPIO SH U 555 C caused a significant increase in signal intensity of the arthritic joints on T1-weighted MR images (p < 0.05). This effect was optimized using a flip angle of 60 - 70°, a minimal TE and a dose of 200 μmol Fe/kg. Visually the contralateral normal knee did not show any USPIO enhancement. Conclusion: Inflammation can be depicted with marked T1 enhancement by the USPIO SH U 555 C using high contrast agent doses and optimized MR pulse sequence parameters.
KW - Animal investigations
KW - Arthritides
KW - Contrast agents
KW - MR imaging
KW - USPIO
UR - http://www.scopus.com/inward/record.url?scp=32544448055&partnerID=8YFLogxK
U2 - 10.1055/s-2005-858634
DO - 10.1055/s-2005-858634
M3 - Artikel
C2 - 16435251
AN - SCOPUS:32544448055
SN - 1438-9029
VL - 178
SP - 200
EP - 206
JO - RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren
JF - RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren
IS - 2
ER -