MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

Matthias Kotzsch; Julia Dorn; Kristina Doetzer; Barbara Schmalfeldt; Janna Krol; Gustavo Baretton; Marion Kiechle; Manfred Schmitt; Viktor Magdolen

doi:10.1515/BC.2011.166

MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

Matthias Kotzsch
, Julia Dorn
, Kristina Doetzer
, Barbara Schmalfeldt
, Janna Krol
, Gustavo Baretton
, Marion Kiechle
, Manfred Schmitt
, Viktor Magdolen

Technische Universität Dresden
Technical University of Munich

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

Original language	English
Pages (from-to)	1047-1051
Number of pages	5
Journal	Biological Chemistry
Volume	392
Issue number	11
DOIs	https://doi.org/10.1515/BC.2011.166
State	Published - 1 Nov 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ovarian cancer
prognosis
quantitative PCR
rab31
uPAR
uPAR-del4/5

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10.1515/BC.2011.166

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Kotzsch, M., Dorn, J., Doetzer, K., Schmalfeldt, B., Krol, J., Baretton, G., Kiechle, M., Schmitt, M., & Magdolen, V. (2011). MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. Biological Chemistry, 392(11), 1047-1051. https://doi.org/10.1515/BC.2011.166

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title = "MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer",

abstract = "High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.",

keywords = "ovarian cancer, prognosis, quantitative PCR, rab31, uPAR, uPAR-del4/5",

author = "Matthias Kotzsch and Julia Dorn and Kristina Doetzer and Barbara Schmalfeldt and Janna Krol and Gustavo Baretton and Marion Kiechle and Manfred Schmitt and Viktor Magdolen",

note = "Funding Information: We thank Antje Zobjack for her excellent technical assistance. This study was in part supported by grants from the Deutsche Krebshilfe, Bonn, Germany (grants 107 965 and 108 050), the Kapitel Klinische Forschung (Klinikum rechts der Isar, TUM), and from the German Federal Ministry of Education and Research, Leading-Edge Cluster m4.",

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doi = "10.1515/BC.2011.166",

language = "English",

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Kotzsch, M, Dorn, J, Doetzer, K, Schmalfeldt, B, Krol, J, Baretton, G, Kiechle, M, Schmitt, M & Magdolen, V 2011, 'MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer', Biological Chemistry, vol. 392, no. 11, pp. 1047-1051. https://doi.org/10.1515/BC.2011.166

MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. / Kotzsch, Matthias; Dorn, Julia; Doetzer, Kristina et al.
In: Biological Chemistry, Vol. 392, No. 11, 01.11.2011, p. 1047-1051.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

AU - Kotzsch, Matthias

AU - Dorn, Julia

AU - Doetzer, Kristina

AU - Schmalfeldt, Barbara

AU - Krol, Janna

AU - Baretton, Gustavo

AU - Kiechle, Marion

AU - Schmitt, Manfred

AU - Magdolen, Viktor

N1 - Funding Information: We thank Antje Zobjack for her excellent technical assistance. This study was in part supported by grants from the Deutsche Krebshilfe, Bonn, Germany (grants 107 965 and 108 050), the Kapitel Klinische Forschung (Klinikum rechts der Isar, TUM), and from the German Federal Ministry of Education and Research, Leading-Edge Cluster m4.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

AB - High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

KW - ovarian cancer

KW - prognosis

KW - quantitative PCR

KW - rab31

KW - uPAR

KW - uPAR-del4/5

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SN - 1431-6730

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JO - Biological Chemistry

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ER -

MRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

Abstract

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Keywords

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