MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis

Thomas Baum; Dimitrios C. Karampinos; Knut Brockow; Vanadin Seifert-Klauss; Pia M. Jungmann; Tilo Biedermann; Ernst J. Rummeny; Jan S. Bauer; Dirk Müller

doi:10.1016/j.clinimag.2014.12.006

MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis

Technical University of Munich
Uniklinikum Köln

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.

Original language	English
Pages (from-to)	886-889
Number of pages	4
Journal	Clinical Imaging
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/j.clinimag.2014.12.006
State	Published - 1 Sep 2015

Keywords

Indolent systemic mastocytosis
Magnetic resonance imaging
Osteoporosis
Trabecular bone microstructure

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10.1016/j.clinimag.2014.12.006

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title = "MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis",

abstract = "Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.",

keywords = "Indolent systemic mastocytosis, Magnetic resonance imaging, Osteoporosis, Trabecular bone microstructure",

author = "Thomas Baum and Karampinos, \{Dimitrios C.\} and Knut Brockow and Vanadin Seifert-Klauss and Jungmann, \{Pia M.\} and Tilo Biedermann and Rummeny, \{Ernst J.\} and Bauer, \{Jan S.\} and Dirk M{\"u}ller",

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doi = "10.1016/j.clinimag.2014.12.006",

language = "English",

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AU - Baum, Thomas

AU - Karampinos, Dimitrios C.

AU - Brockow, Knut

AU - Seifert-Klauss, Vanadin

AU - Jungmann, Pia M.

AU - Biedermann, Tilo

AU - Rummeny, Ernst J.

AU - Bauer, Jan S.

AU - Müller, Dirk

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.

AB - Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.

KW - Indolent systemic mastocytosis

KW - Magnetic resonance imaging

KW - Osteoporosis

KW - Trabecular bone microstructure

UR - https://www.scopus.com/pages/publications/84940453688

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DO - 10.1016/j.clinimag.2014.12.006

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JO - Clinical Imaging

JF - Clinical Imaging

IS - 5

ER -

MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis

Abstract

Keywords

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