MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis

Thomas Baum; Dimitrios C. Karampinos; Knut Brockow; Vanadin Seifert-Klauss; Pia M. Jungmann; Tilo Biedermann; Ernst J. Rummeny; Jan S. Bauer; Dirk Müller

doi:10.1016/j.clinimag.2014.12.006

MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis

Thomas Baum, Dimitrios C. Karampinos, Knut Brockow, Vanadin Seifert-Klauss, Pia M. Jungmann, Tilo Biedermann, Ernst J. Rummeny, Jan S. Bauer, Dirk Müller

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Abstract

Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.

Original language	English
Pages (from-to)	886-889
Number of pages	4
Journal	Clinical Imaging
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/j.clinimag.2014.12.006
State	Published - 1 Sep 2015

Keywords

Indolent systemic mastocytosis
Magnetic resonance imaging
Osteoporosis
Trabecular bone microstructure

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10.1016/j.clinimag.2014.12.006

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title = "MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis",

abstract = "Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.",

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author = "Thomas Baum and Karampinos, {Dimitrios C.} and Knut Brockow and Vanadin Seifert-Klauss and Jungmann, {Pia M.} and Tilo Biedermann and Rummeny, {Ernst J.} and Bauer, {Jan S.} and Dirk M{\"u}ller",

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doi = "10.1016/j.clinimag.2014.12.006",

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AU - Baum, Thomas

AU - Karampinos, Dimitrios C.

AU - Brockow, Knut

AU - Seifert-Klauss, Vanadin

AU - Jungmann, Pia M.

AU - Biedermann, Tilo

AU - Rummeny, Ernst J.

AU - Bauer, Jan S.

AU - Müller, Dirk

PY - 2015/9/1

Y1 - 2015/9/1

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AB - Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting.

KW - Indolent systemic mastocytosis

KW - Magnetic resonance imaging

KW - Osteoporosis

KW - Trabecular bone microstructure

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ER -

MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis

Abstract

Keywords

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