Mouse genetics and metabolic mouse phenotyping

Helmut Fuchs, Susanne Neschen, Jan Rozman, Birgit Rathkolb, Sibylle Wagner, Thure Adler, Luciana Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Alexander Bohla, Julia Calzada-Wack, Christian Cohrs, András Frankó, Lillian Garrett, Lisa Glasl, Alexander Götz, Michael Hagn, Wolfgang Hans, Sabine M. Hölter, Marion HorschMelanie Kahle, Martin Kistler, Tanja Klein-Rodewald, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Gabriele Möller, Beatrix Naton, Frauke Neff, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Michael Räß, Markus Scheerer, Evelyn Schiller, Felix Schöfer, Anja Schrewe, Ralph Steinkamp, Claudia Stöger, Irina Treise, Monja Willershäuser, Annemarie Wolff-Muscate, Ramona Zeh, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Jack Favor, Jochen Graw, Hugo Katus, Thomas Klopstock, Markus Ollert, Holger Schulz, Tobias Stöger, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Eckhard Wolf, Martin Klingenspor, Valérie Gailus-Durner, Martin Hrabě De Angelis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The mouse is widely considered as a toolbox for modeling human diseases: mice are easy to handle and breed, there exist inbred strains, and the mouse genome sequence is available. Mutant mouse lines can be generated by different technologies, and standardized phenotyping of these mutant mouse lines produces a huge amount of valuable data. Useful resources for the scientific community are archives of mutant lines and strains as well as databases delivering information about the mouse lines and their availability. The phenotypic characterization of mutant mouse lines is the bottleneck within the pipeline from the generation via phenotyping to archiving of mutant mouse lines. Mouse clinics generate large data sets by the standardized, comprehensive phenotypic characterization of mutant mouse lines. There is a portfolio of phenotyping protocols available for a broad spectrum of disease areas that is considered as an international standard. For the investigation of human diseases like diabetes, obesity or the metabolic syndrome, metabolic tests to analyze mutant mouse lines become increasingly important. In this respect, challenge experiments have become the major focus to induce disease phenotypes in mutant mice that would remain undiscovered without the environmental challenges. These experimental setups reflect human conditions, where genetic predisposition and the environmental factors originating from different life style act together and enhance each other.

Original languageEnglish
Title of host publicationGenetics Meets Metabolomics
Subtitle of host publicationFrom Experiment to Systems Biology
PublisherSpringer New York
Number of pages22
ISBN (Electronic)9781461416890
ISBN (Print)1461416884, 9781461416883
StatePublished - 1 Jul 2014


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